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Alpha-1 adrenergic function in hemodynamic control of stroke-prone spontaneously hypertensive rats (SHRSP)
https://kindai.repo.nii.ac.jp/records/2003071
https://kindai.repo.nii.ac.jp/records/200307178c2deec-4bf9-49e8-bee1-8962dcc09c43
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19961200-0303.pdf (900.8 KB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||||
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| 公開日 | 2025-07-07 | |||||||||
| タイトル | ||||||||||
| タイトル | Alpha-1 adrenergic function in hemodynamic control of stroke-prone spontaneously hypertensive rats (SHRSP) | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Hishida, Morihiko
× Hishida, Morihiko
× Higashino, Hideaki
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| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | methoxamine, bunazosin, SHRSP, α1-agonist, α1-antagonist, radio-labeled microsphere method, hypertension | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | At the initial stage of hypertension in spontaneously hypertensive rat (SHR) strains, hyperactivity in the sympathetic nervous system, an increase of norepinephrine release into the blood, decreases of norepinephrine and dopamine contents in the brain stem, hyperresponses to α1-adrenergic agents in the aorta, femoral artery, and portal vein were reported. To elucidate the mechanisms to develop hypertension, α1-adrenergic vasocontractile function in SHR strains was parformed by a radiolabeled microsphere method on the stimulation of α1-agonist, methoxamine, or inhibition by α1-blocker, bunazosin, in 6-month-old SHRSP. The results were as follows. 1) There was no difference in the response of the central and peripheral hemodynamics to α1-agonist, methoxamine, and in the activities of the intrinsic α1-adrenergic system estimated by the administration of bunazosin between SHRSP and normotensive Wistar Kyoto rats (WKY). 2) Blood pressure elevated by α1-agonist largely contributed to the increase of brain blood flow. 3) Lower circulation in the brain of SHRSP than in WKY was observed. 4) The effect of α1-agonist such as methoxamine on the kidney, gastrointestinal tract, spleen, muscle, and skin of SHRSP was insignificant. The above suggests that intrinsic α1-agonist such as norepinephrine in the peripheral tissues was not a main factor for the cause or continuance of hypertension in 6-month-old SHRSP. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||
| 言語 | en | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03866092 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 303 | |||||||||
| 終了ページ | ||||||||||
| 終了ページ | 313 | |||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 21, 号 4, p. 303-313, 発行日 1996-12 |
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