| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-07-07 |
| タイトル |
|
|
タイトル |
L-arginine produces antinociceptive effects in spinal cord of rats |
|
言語 |
en |
| 作成者 |
Okuda, Takahiko
Wakita, Katsutoshi
Tsuchiya, Norio
Hatsuoka, Kazuki
Koga, Yoshihisa
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
L-arginine, antinociception, spinal cord |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The antinociceptive effects of intrathecal (i.t.) administration of L-arginine were investigated in rats. When assessed with the tail-flick test, i.t. administration of 1000 μg L-arginine had significant antinociceptive effects in rats. At a lower dose (100 μg), L-arginine failed to suppress the nociceptive response. When similarly treated, however, D-arginine (1000 μg) failed to suppress the nociceptive response. Furthermore, suppressive effects with 1000 μg of L-arginine were significantly reversed by naloxone (10 μg ; i.t.) pretreatment. It is, therefore, speculated that L-arginine-induced suppression of nociception in the spinal cord is mediated through the activation of opioid receptors. These findings suggest that L-arginine plays a important role in processing nociceptive inputs in the spinal cord. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
235 |
| 終了ページ |
|
|
終了ページ |
238 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 21,
号 3,
p. 235-238,
発行日 1996-09
|
AA0050842X-19960900-0235.pdf (333.2 KB)
