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Behavioral and morphological alterations in rats prenatally treated with methylazoxymethanol acetate (MAM)
https://kindai.repo.nii.ac.jp/records/2003060
https://kindai.repo.nii.ac.jp/records/20030602f40beda-c9d0-4aed-a0fa-980fd090ec40
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19960900-0205.pdf (2.4 MB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-07-07 | |||||||
| タイトル | ||||||||
| タイトル | Behavioral and morphological alterations in rats prenatally treated with methylazoxymethanol acetate (MAM) | |||||||
| 言語 | en | |||||||
| 作成者 |
Yamamoto, Yoshitame
× Yamamoto, Yoshitame
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | Prenatal MAM exposure, Micrencephaly, Rat, Hyperactivity, Maldevelopment of the brain | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Methylazoxymethanol acetate (MAM) is an aglycon of cycasine contained in the cycad seed, and cytotoxic against neuroblasts. In order to investigate brain function impairments (especially hyperactivity), MAM was administered once intraperitoneally at 30mg/kg to female Crj-CD rats on Days 12,13,15,and 18 of gestation (Day 0=day of observation of vaginal plug). In the pups exposed to MAM on Day 13 of gestation, reflexes and motor coordination before weaning, and the activity level and learning ability after weaning were studied. In the pups exposed to MAM on Days 12,15,and 18 of gestation, activity level before weaning were analyzed, and brain tissue damage was studied 8 weeks after birth. The effects of MAM exposure on both the absolute and relative brain weights were greatest in those exposed on Day 12. Changes in skeletal development in the pups exposed to MAM on Day 13 of gestation were limited to the cranial region. Morphological abnormalities of the presphenoid bone in the cranial base were observed, suggesting impaired development extending to the central optic tract. Temporary delays of the reflex development of the pups exposed to MAM on Day 13 of gestation were noted. Similarly, delays in the development of limb motor coordination were observed in males 18-21 days after birth in a swimming test. The activity level in an open-field test was significantly higher in the animals exposed to MAM on Days 12,13,and 15 of gestation as compared with the controls. The increase in the activity level at weaning was the most notable. Learning (memory) on single T-maze and multiple T-maze tasks in the animals exposed to MAM on Day 13 of gestation was slower than in the control group. Various brain tissue abnormalities such as heterotopic aggregation of neurons and disturbance of fiber arrangement were noted in the cerebral cortex and the hippocampus of the animals exposed to MAM on Day 15 of gestation. These findings suggest that animal models of various impairments of brain development including congenital micrencephaly syndrome and hyperactive pups can be produced by appropriate selection of the time of exposure to MAM. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 205 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 228 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 21, 号 3, p. 205-228, 発行日 1996-09 |
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