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Effect of reperfusion 12 hours after coronary occlusion on myocardial salvage in dogs
https://kindai.repo.nii.ac.jp/records/2003059
https://kindai.repo.nii.ac.jp/records/20030594ac4a347-c798-4180-a7f7-a1c1d2b095bb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19960900-0193.pdf (1.1 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-07-07 | |||||||
| タイトル | ||||||||
| タイトル | Effect of reperfusion 12 hours after coronary occlusion on myocardial salvage in dogs | |||||||
| 言語 | en | |||||||
| 作成者 |
Kamata, Noriaki
× Kamata, Noriaki
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | myocardial infarction, late reperfusion, myocardial salvage, regional myocardial blood flow, non-radioactive colored microsphere | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Late reperfusion therapy in acute myocardial infarction (AMI) has been generally considered not effective on the salvage of myocardial necrosis. However, the salvage by late reperfusion would be possible if the development of necrosis was relatively late and the myocardium remained viable until reperfusion. To test this hypothesis, we performed the experiment of myocardial reperfusion 12 hours after occlusion of the left anterior descending coronary artery in dogs. Twenty five dogs were divided into two groups ; in group A (n=12) the artery remained occluded for 4 weeks and in group B (n=13) it was reperfused 12 hours after occlusion. Regional myocardial blood flow (Qm) was measured using the colored microsphere method. The heart was removed at 4 weeks, and three indices, consisting of myocardial creatine kinase activity (CK), infarct size determined by the triphenyl tetrazolium chloride (TTC) stain and histological extent of fibrosis, were measured to determine the extent of necrosis. In the inner layer, infarct size and myocardial CK showed no difference between the groups, while the extent of fibrosis was significantly less in group B than in group A. At the middle layer, although infarct size was similar in both groups, myocardial CK was higher in group B than in group A and the extent of fibrosis was less in the former than in the latter. A similar result was shown in the outer layer, where myocardial CK was greater in group B than in group A and the extent of fibrosis was less in the former than in the latter. A significant reduction of fibrosis in all 3 layers and a higher myocardial CK in the middle and outer layers in group B may be attributed to myocardial salvage by late reperfusion. Thus, it is suggested that late reperfusion therapy has beneficial effects on myocardial salvage in AMI. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 193 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 203 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 21, 号 3, p. 193-203, 発行日 1996-09 |
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