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Pharmacological investigation of peptide-induced vasorelaxation in the isolated intrarenal arteries of stroke-prone spontaneously hypertensive rats
https://kindai.repo.nii.ac.jp/records/2003052
https://kindai.repo.nii.ac.jp/records/20030525fd5ecaf-4ef9-493b-bf7a-660f5ab2769c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19960600-0123.pdf (1.1 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-07-07 | |||||||
| タイトル | ||||||||
| タイトル | Pharmacological investigation of peptide-induced vasorelaxation in the isolated intrarenal arteries of stroke-prone spontaneously hypertensive rats | |||||||
| 言語 | en | |||||||
| 作成者 |
Gao, Yujing
× Gao, Yujing
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), calcitonin gene-related peptide (CGRP), intrarenal artery, SHRSP, vasoactive intestinal peptide (VIP), vasorelaxation | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | This study was designed to investigate the effects of various vasodilator peptides in the isolated intrarenal arteries (IRA) of stroke-prone spontaneously hypertensive rats (SHRSP). In noradrenaline-precontracted IRA of 6-7 month old rats, calcitonin gene-related peptide (CGRP) provoked significantly greater endothelium-independent relaxation in SHRSP than in Wistar-Kyoto rats (WKY) with pD₂ estimates of 8.85 and 8.13 respectively (p<0.01). This relaxation was reversibly inhibited by human CGRP₈₋₃₇ (10⁻⁶ M), a CGRP₁ receptor antagonist. Amylin amide and adrenomedullin also produced greater relaxation in SHRSP than in WKY with pD₂ values of 7.59 and 7.4 for SHRSP and of 7.04 and 7.02 for WKY, respectively (p<0.01). No significant differences between SHRSP and WKY were observed in the endothelium-independent relaxation responses to atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), c-type natriuretic peptide, vasoactive intestinal peptide (VIP), and peptide histidine isoleucine. Bradykinin produced minor endothelium-dependent vasodilation similarly in the two strains. Substance P and neurokinin A did not relax the IRA at all. Furthermore, response to CGRP was also evaluated in younger SHRSP. It was found that reactivity to CGRP was still significantly greater in SHRSP aged 3 and 1.5 months than in age-matched WKY. In addition, a notable decline in the magnitude of CGRP-induced response was found in WKY as the age increased from 1.5 to 6-7 months, whereas in SHRSP no such age-related decrease was observed. Neither significant differences between the two strains nor significant age-dependent variations in either strain were found in relaxation responses to dibutyryl cyclic AMP, forskolin, and 3-isobutyl-1-methylxanthine. Incubation with glibenclamide (10⁻⁶ M) did not affect CGRP-induced relaxation in both SHRSP and WKY at all the ages used. In summary, the present results show that several peptides, such as CGRP, ANP, BNP, and VIP, are able to relax rat IRA remarkably, suggesting their possible role in modulating intrarenal vascular tone. In SHRSP, a significantly increased relaxation response to CGRP₁ receptor stimulation and lack of age-related reduction of this enhanced response are demonstrated. These changes found in SHRSP may not be a post-receptor event relating to second messengers like cyclic AMP, or to ATP-dependent potassium channels. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 123 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 137 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 21, 号 2, p. 123-137, 発行日 1996-06 |
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