| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-07-07 |
| タイトル |
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|
タイトル |
The inhibitory effects of female sex hormones on urinary stone formation in rats |
|
言語 |
en |
| 作成者 |
Takamura, Chisato
Iguchi, Masanori
Kurita, Takashi
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
urolithiasis, female sex hormones |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
There is no sex difference in the incidence of urolithiasis in childhood or climacterium, but the male to female ratio has been reported to be approximately 3 : 1 during the reproductive stage. This suggests that female sex hormones inhibit stone formation. Based on this observation, the influences of female sex hormones on stone formation were investigated in female rats with experimentally induced stones. Oophorectomized groups (A and C) and non-oophorectomized groups (B and D) were prepared. Stones were induced by administering vitamin D3 and ethylene glycol for 12 weeks in Groups A and B, and for 4 weeks in Groups C and D. Groups E and G were prepared in a similar manner to Group C, and Group F was prepared in a similar manner to Group D. To supply the female sex hormones, estrogen and progesterone were also given to Group G. The degree of stone formation was determined histologically ; simultaneously, bone mineral content was determined with microdensitometry. The levels of various other stone-related substances, estradiol and hydroxyproline, as well as calcium content in renal tissue were measured. Osteopontin m-RNA in renal tissues was also determined by Northern blot technique. The urinary excretion of citric acid and bone mineral content were decreased and the incidence of stone formation was increased in oophrectomized rats. Stone formation in renal tissue and the appearance of osteopontin, a component of stone matrix, were inhibited by female sex hormones supplements. These results suggest that the low incidence of urolithiasis in women of reproductive age is attributable to female sex hormones. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
77 |
| 終了ページ |
|
|
終了ページ |
84 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 21,
号 2,
p. 77-84,
発行日 1996-06
|
AA0050842X-19960600-0077.pdf (911.0 KB)
