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Relationship between effects of stress on airway hyperresponsiveness and inflammatory cells in an experimental guinea pig asthma model
https://kindai.repo.nii.ac.jp/records/2003038
https://kindai.repo.nii.ac.jp/records/2003038429fe8bb-fd76-4603-af58-18377aea3e9c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19960300-0001.pdf (1.1 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-07-04 | |||||||
| タイトル | ||||||||
| タイトル | Relationship between effects of stress on airway hyperresponsiveness and inflammatory cells in an experimental guinea pig asthma model | |||||||
| 言語 | en | |||||||
| 作成者 |
Tanaka, Akira
× Tanaka, Akira
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | experimental asthma model, airway hyperresponsiveness, stress, macrophages, lymphocytes, psychoneuroimmunology | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | In recent years, bronchial asthma has come to be regarded as an airway inflammation. It is thought that stress accelerates this mechanism and elevates airway reactivity, and that nervous, endocrine, and immune systems are involved in these stress-associated events. In the present study, airway reactivity following exposure to stress was examined in a guinea pig model of asthma. Furthermore, we examined the chemotaxis and phagocytosing activity of macrophages (an airway defensive factor) and analyzed the intracellular signal transmission system on the basis of measurement of cAMP and IP3 levels, with the goal of assessing the effects of stress. Moreover, analysis of cell kinetics in bronchoalveolar lavage fluid and immunohistochemical examination of T lymphocyte invasion of lungs were carried out. Exposure of guinea pigs to stress elevated their airway reactivity, suggesting that stress can cause the onset or exacerbation of bronchial asthma. The chemotaxis of macrophages was suppressed by stress, probably through the stress-induced release of glucocorticoid. The level of IP3,known to serve as the second messenger of muscarinic acetylcholine receptors, was elevated by stress, suggesting stress-induced stimulation of parasympathetic nerves. An increase of lymphocytes and eosinophils in bronchoalveolar lavage fluid was observed from 2 hours after stress. Immunohistological staining of lungs revealed T lymphocytes induction. These results suggest that autonomic, endocrine and immune systems are involved in the body's responses to stress, that stimulation of the parasympathetic nerves is particularly important in the elevation of airway reactivity, and that stress causes activation of lymphocytes (particularly T cells) in the airway. It seems likely that airway reactivity is elevated by the stress-induced activation of T lymphocytes and eosinophils, and by the transfer of various inflammatory cells. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 1 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 13 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 21, 号 1, p. 1-13, 発行日 1996-03 |
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