| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-06-24 |
| タイトル |
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|
タイトル |
A mechanism and clinical implications of exercise-induced ST-segment elevation in patients recovering from myocardial infarction |
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言語 |
en |
| 作成者 |
Katori, Ryo
Miyazaki, Toshio
Yamashita, Keizo
Inoki, Tatsu
Yamamoto, Tadahiko
Shibutani, Toshiyuki
Hioki, Junya
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| 言語 |
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|
言語 |
eng |
| キーワード |
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主題 |
exercise, ST-segment elevation, myocardial infarction, β-adrenergic activity, norepinephrine, isoproterenol, myocardial ischemia, wall motion abnormality, action potentials, myocardial blood flow |
| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background Exercise-induced ST-segment elevation is not uncommon in patients after myocardial infarction. Concerning the mechanism, myocardial ischemia and wall motion abnormality have been discussed for two decades but both are highly controversial. We are proposing a novel mechanism that the ST elevation may result from an enhanced β-adrenergic activity in peri-infarct and noninfarct areas. Methods The patients with prior myocardial infarction underwent exercise tests and isoproterenol infusion while the electrocardiograms, hemodynamics and left ventricular wall motion were measured. To investigate experimentally the mechanism of the ST elevation during the interventions such as catecholamine infusions and treadmill exercise, we measured regional myocardial blood flow and wall motion abnormalities and electrocardiographic changes using a canine model of myocardial infarction produced by LAD embolization. Long-term prognosis after myocardial infarction was surveyed in relation to exercise-induced ST-segment shifts. Results The patients with ST elevation achieved higher exercise levels associated with augmented sympathetic activity than the other patient groups. Isoproterenol infusion induced a distinct ST-segment elevation which is quite similar to that induced by exercise in both the patient and canine models without myocardial ischemia and aggravation of wall motion abnormality. Regional myocardial blood flow and wall motion in the peri-infarct region were enhanced by isoproterenol and exercise. The survival rate and follow-up cardiac events were better in patients with ST elevation than in those with ST depression. Conclusions ST-segment elevation was induced without myocardial ischemia and aggravation of wall motion abnormality by both infusion of isoproterenol and exercise in the canine model and patients with myocardial infarction. It is concluded that enhanced β-adrenergic activity can cause ST-segment elevation. |
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言語 |
en |
| 出版者 |
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出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03866092 |
| 開始ページ |
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|
開始ページ |
247 |
| 終了ページ |
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終了ページ |
281 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 22,
号 4,
p. 247-281,
発行日 1997-12
|
AA0050842X-19971200-0247.pdf (3.4 MB)
