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Absorption and Metabolism of Insulin (Review)
https://kindai.repo.nii.ac.jp/records/2003004
https://kindai.repo.nii.ac.jp/records/20030044fc036f5-2c4e-4723-9330-fcf953090d85
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19970900-0197.pdf (479.0 KB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||
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| 公開日 | 2025-06-23 | |||||||||
| タイトル | ||||||||||
| タイトル | Absorption and Metabolism of Insulin (Review) | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Aoki, Norihiko
× Aoki, Norihiko
× Saika, Toyohiko
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| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | Insulin, Absorption, Clearance, Resistance, Liver, Kidney | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | In the interim between the first clinical introduction of insulin in 1921 to the recent report of the Diabetes Control and Complications Trial in 1993, insulin firmly established a pivotal position in the control of diabetes and related complications. However, there have been several critical reports, including for example, reports dealing with syndrome X, which recently warned about the possible adverse effects of excessive insulin supply. Accordingly, contemporary clinicians should obtain as much information as possible concerning the actual kinetics of insulin, and apply up-to-date knowledge to all clinical practices which use insulin preparations. From the current opinion, the appearance of exogenous insulin in the circulation after administration should be as fast and natural as possible. Future disign of insulin preparations and their routes of administration should mimic natural secretion and the action of endogenous insulin. In addition, the insulinresistant state should be viewed as a key to a variety of diabetic vessel diseases and interpreted in conjunction with dysfunction of the liver, muscle, fatty tissue, and kidney. Regarding the disposal of insulin in which both receptormediated and non-receptor-mediated routes are observed, the liver plays the most important role followed by the kidney the next, explaining hyperinsulinemia in liver diseases and augmentation of insulin action in renal diseases. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||
| 言語 | en | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03866092 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 197 | |||||||||
| 終了ページ | ||||||||||
| 終了ページ | 201 | |||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 22, 号 3, p. 197-201, 発行日 1997-09 |
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