| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-06-23 |
| タイトル |
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|
タイトル |
Effect of a single intravenous dose of bisphosphonate (pamidronate) on tibial cortical bone after lengthening |
|
言語 |
en |
| 作成者 |
Miyazaki, Hiroshi
Hamanishi, Chiaki
Yoshii, Takeo
Tanaka, Seisuke
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Bisphosphonate, Osteogenesis, Osteoporosis, Bone lengthening |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
The tibiae of 15 young rabbits were osteotomized and lengthened gradually to produce a gap of 1 cm over a period of 10 days, and then one dose of 0.6 mg/kg of bisphosphonate (pamidronate disodium) was injected intravenously into 5 of them. The bone mineral density (BMD) in the proximal and distal portions of the tibia and lengthened callus was evaluated using dual energy X-ray absorptiometry every 5 days for 30 days after lengthening had been completed. In the control rabbits the BMD in the distal and proximal diaphyseal portions of the tibiae continuously decreased to about 50% 15 days after completion of lengthening. In the treated rabbits, however, the BMD increased until day 10 in the proximal portion and until day 5 in the distal portion, with the difference being significant in the proximal portion. It was demonstrated that a single pamidronate dose could inhibit bone resorption in an area of high bone turnover. The stimulatory effect of a single dose on the mineralization of the lengthened callus, however, was not significant. Experiments using repetitive doses of pamidronate for longer periods should be mandatory. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
155 |
| 終了ページ |
|
|
終了ページ |
158 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 22,
号 2,
p. 155-158,
発行日 1997-06
|
AA0050842X-19970600-0155.pdf (372.5 KB)
