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Immune reactions in patients with primary lung cancer : analysis of lymphocyte subsets in bronchoalveolar lavage fluid and peripheral blood
https://kindai.repo.nii.ac.jp/records/2002996
https://kindai.repo.nii.ac.jp/records/2002996798045ed-13d4-40a8-9824-2c8562385503
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19970600-0137.pdf (930.0 KB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-06-23 | |||||||
| タイトル | ||||||||
| タイトル | Immune reactions in patients with primary lung cancer : analysis of lymphocyte subsets in bronchoalveolar lavage fluid and peripheral blood | |||||||
| 言語 | en | |||||||
| 作成者 |
Nogami, Toshiji
× Nogami, Toshiji
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | Lung cancer, Lymphocyte subsets, Memory T cell, Naive T cell | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Lymphocyte subsets analysis was performed using bronchoalveolar lavage fluid (BALF) and peripheral blood of patients with primary lung cancer, and immunological responses of tumor-bearing hosts were evaluated. In the peripheral blood of lung cancer patients, the lymphocyte count was significantly reduced with a decrease in CD4+ T cells among lymphocyte subsets as compared with healthy individuals. In the CD4+ T cell subset, CD4+CD29+ (helper, CD4+ memory) T cells and CD4+CD45RA+ (suppressor/inducer, naive) T cells were significantly reduced in the lung cancer patients. In the CD8+ T cell subset, CD8+CD28+ (immature cytotoxic) T cells were significantly reduced. However, activated CD4+ and CD8+ T cells were increased in the lung cancer patients, suggesting that the tumor may have been recognized by the systemic immune system of the patients, and that lymphocytes may have migrated to the tumor. In the BALF of lung cancer patients, lymphocytes were significantly increased, and activated CD4+CD45RO+ (CD4+ memory) T cells were increased, as compared with the healthy controls. No significant difference was observed in the number of CD8+ T cells as compared with healthy controls, and the number of CD8+CD11b- (cytotoxic) T cells and CD8+CD45RO+ (CD8+ memory) T cells were similar to those in the healthy controls ; but their absolute number was increased. These findings suggest a reduction in systemic immunological competence due to depression of the immunosurveillance mechanism associated with the decrease in peripheral blood lymphocytes and enhancement of regional immunological competence in the lung. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 137 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 147 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 22, 号 2, p. 137-147, 発行日 1997-06 |
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