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Retinoid induces growth inhibition of adult T-cell leukemia cells
https://kindai.repo.nii.ac.jp/records/2002992
https://kindai.repo.nii.ac.jp/records/200299271444e2f-fc97-4b6e-96fc-4aaed7fc4eae
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19970300-0111.pdf (852.5 KB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||||
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| 公開日 | 2025-06-23 | |||||||||
| タイトル | ||||||||||
| タイトル | Retinoid induces growth inhibition of adult T-cell leukemia cells | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Miyatake, Jun-ichi
× Miyatake, Jun-ichi
× Maeda, Yasuhiro
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| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | retinoic acid, ATL, thiol compounds, CD25 expression, antiproliferative effect | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The effects of retinoic acid (RA) on the cell growth and expression of interleukin-2 (IL-2) receptor (IL-2Rα/p55,Tac, CD25) by the human T lymphotropic virus type I positive (HTLV-I(+)) T cell lines, HUT102 and ATL-2, were investigated. Incubation of these cells with RA resulted in marked growth inhibition and down-regulation of CD25 expression. Four clones of HUT102 cell lines were established by limiting dilution, and RA was shown to inhibit the growth and CD25 expression in three of these clones, but in the fourth. However, RA did not induce growth inhibition of the HTLV-I-negative T cell lines, MOLT-4 and Jurkat, and of normal lymphocytes that had been stimulated wih phytohemagglutinin. We hydothesized that the sensivity to retinoids depends on an imbalance in intracellular redox potential. To examine the effect of exogenous thiol compounds for the growth inhibition of HTLV-I(+) T cell lines induced by RA, these cell lines were cultured with serveral thiol compounds (ATL-derived factor, thioredoxin, L-cystine and glutathione (GSH)), following the addition of RA in thiol-free medium. Unexpectedly, thiol compounds alone, when added after RA, did not restore the growth inhibition of HTLV-I(+) T cell lines induced by RA. However, when those cells were preincubated with thiol compounds for 24 hrs, no RA-induced growth inhibition was observed. These findings suggest that intracellular reductive environments induced by thiol compounds are associated with resistance to RA of HTLV-I(+) T cells, and that thiol compounds may play an important role in HTLV-I(+) T cell proliferation. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||
| 言語 | en | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03866092 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 111 | |||||||||
| 終了ページ | ||||||||||
| 終了ページ | 121 | |||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 22, 号 1, p. 111-121, 発行日 1997-03 |
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