| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-06-23 |
| タイトル |
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|
タイトル |
Characterization of dopamine-induced vasorelaxation in isolated renal arteries from stroke-prone spontaneously hypertensive rats |
|
言語 |
en |
| 作成者 |
Futami, Kunihiko
Nishimura, Yoshitaka
Higashino, Hideaki
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
dopamine, DA1 receptor, renal artery, stroke-prone spontaneously hypertensive rat, vasorelaxation |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
The dopamine (DA)-induced relaxation in ring preparations of main renal arteries (MRA) and intrarenal arteries (IRA) from stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto rats (WKY) was pharmacologically investigated in animals at 1.5,3 and 6 months of age. DA elicited endothelium-independent relaxation in MRA and IRA pretreated with phenoxybenzamine from SHRSP and WKY at 1.5 months of age, and the relaxant responses in both arteries were significantly greater in SHRSP than in WKY. The DA-induced relaxations in MRA SHRSP and WKY were almost negligible at 3 months of age and were not found at 6 months of age. In IRA, the DA-induced relaxation was age-dependently attenuated in SHRSP and WKY, and the degree of attenuation was greater in WKY than in SHRSP. The DA-induced relaxations in MRA and IRA from WKY and SHRSP were inhibited by SCH 23390,a DA1 receptor antagonist, but not by sulpride, a DA2 receptor antagonist. The relaxations produced by SKF 38393,a DA1 receptor agonist, in MRA and IRA were greater in SHRSP at 1.5 months of age than in age-matched WKY. In addition, the pattern of age-related alterations in relaxations produced by SKF 38393 was similar to that produced by DA. Bromocriptine, a DA2 receptor agonist, did not elicit relaxation in MRA and IRA from either group. There were no significant differences in relaxation in response to the cyclic AMP-generating system affecting drugs (forskolin, dibutyryl cyclic AMP and 3-isobutyl-1-methyxanthine) between SHRSP and age-matched WKY in MRA and IRA at any age tested, and the responses to these drugs in MRA and IRA were not affected by ageing in either group. In conclusion, the DA1-receptor mediated vasorelaxation in renal arteries is greater in SHRSP than in WKY. In addition, there are regional and strain differences in the degree of attenuation of the DA1 receptors mediating relaxation in association with increasing age. Thus, the enhanced DA1 receptor-mediated response in renal arteries from SHRSP may be a compensatory mechanism for the increased renal vascular resistance and reactivities associated with hypertension. Furthermore, the alterations of DA1 receptor-mediated relaxant responses in renal arteries from WKY and SHRSP may be associated with the change in the number of receptors or their coupling to adenylate cyclase, rather than a post-receptor event in the adenylate cyclase/cyclic AMP pathway. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03866092 |
| 開始ページ |
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|
開始ページ |
73 |
| 終了ページ |
|
|
終了ページ |
86 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 22,
号 1,
p. 73-86,
発行日 1997-03
|
AA0050842X-19970300-0073.pdf (1.0 MB)
