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Hypothermia depresses hemodynamics but might not depress hepatic metabolism in dogs
https://kindai.repo.nii.ac.jp/records/2002988
https://kindai.repo.nii.ac.jp/records/2002988993aefee-5298-43a2-a849-46cbddecdbb3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19970300-0067.pdf (356.9 KB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||||||
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| 公開日 | 2025-06-23 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Hypothermia depresses hemodynamics but might not depress hepatic metabolism in dogs | |||||||||||||
| 言語 | en | |||||||||||||
| 作成者 |
Higashizawa, Tomoaki
× Higashizawa, Tomoaki
× Kawata, Keiji
× Izumi, Takafumi
× Koga, Yoshihisa
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| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | hypothermia, hemodynamics, hepatic blood flow, lidocaine, monoethylglycinexylidide (MEGX) | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | The present study investigates the changes of hemodynamics at 37,33,29 and 25℃, and of lidocaine administration on hepatic blood flow, at each hypothermic state in dogs. Cardiac output significantly decreased from 2.66±0.26 at 37℃ to 1.45±0.10 l/min at 25℃ (p<0.01), hepatic blood flow decreased from 15.0±1.2 to 10.6±1.0 ALF unit (p<0.01) and mean arterial pressure decreased from 131±8 to 100±7 mmHg (p<0.01). Mean pulmonary arterial pressure, red cell count and hematocrit showed no significant change at 25℃ compared with those at 37℃. Maximum plasma concentration of monoethylglycinexylidide (lidocaine metabolite) increased at 25℃ (280±23 ng/ml) in comparison with that maximum concentration at 37℃ (144±18 ng/ml, p<0.01), and plasma lidocaine concentration was also higher at 25℃ (1.13±0.17 μg/ml) than at 37℃ (0.07±0.05 μg/ml, p<0.01). These findings indicate that decreased body temperature depresses hemodynamics in dogs, and that not only lidocaine but also MEGX concentrations were increased by cooling. | |||||||||||||
| 言語 | en | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||||||
| 言語 | en | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 03866092 | |||||||||||||
| 開始ページ | ||||||||||||||
| 開始ページ | 67 | |||||||||||||
| 終了ページ | ||||||||||||||
| 終了ページ | 71 | |||||||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 22, 号 1, p. 67-71, 発行日 1997-03 |
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