| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-06-23 |
| タイトル |
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|
タイトル |
Hypothermia depresses hemodynamics but might not depress hepatic metabolism in dogs |
|
言語 |
en |
| 作成者 |
Higashizawa, Tomoaki
Kawata, Keiji
Izumi, Takafumi
Koga, Yoshihisa
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
hypothermia, hemodynamics, hepatic blood flow, lidocaine, monoethylglycinexylidide (MEGX) |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
The present study investigates the changes of hemodynamics at 37,33,29 and 25℃, and of lidocaine administration on hepatic blood flow, at each hypothermic state in dogs. Cardiac output significantly decreased from 2.66±0.26 at 37℃ to 1.45±0.10 l/min at 25℃ (p<0.01), hepatic blood flow decreased from 15.0±1.2 to 10.6±1.0 ALF unit (p<0.01) and mean arterial pressure decreased from 131±8 to 100±7 mmHg (p<0.01). Mean pulmonary arterial pressure, red cell count and hematocrit showed no significant change at 25℃ compared with those at 37℃. Maximum plasma concentration of monoethylglycinexylidide (lidocaine metabolite) increased at 25℃ (280±23 ng/ml) in comparison with that maximum concentration at 37℃ (144±18 ng/ml, p<0.01), and plasma lidocaine concentration was also higher at 25℃ (1.13±0.17 μg/ml) than at 37℃ (0.07±0.05 μg/ml, p<0.01). These findings indicate that decreased body temperature depresses hemodynamics in dogs, and that not only lidocaine but also MEGX concentrations were increased by cooling. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03866092 |
| 開始ページ |
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|
開始ページ |
67 |
| 終了ページ |
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|
終了ページ |
71 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 22,
号 1,
p. 67-71,
発行日 1997-03
|
AA0050842X-19970300-0067.pdf (356.9 KB)
