| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-06-23 |
| タイトル |
|
|
タイトル |
The cytotoxic effect of adriamycin is not attributable to the inhibition of protein kinase C |
|
言語 |
en |
| 作成者 |
Otsuka, Masatomo
Shigeoka, Hironori
Okuno, Kiyotaka
Watatani, Masahiro
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
adriamycin, kinase C, MARCKS, c-fos, phorbol 12-myristate 13-acetate, phosphorylation |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Adriamycin is an antineoplastic drug that appears to exert its biological effects through multiple biochemical mechanisms. We examined possible ability of adriamycin to inhibit protein kinase C activity in BALB/3T3 mouse fibroblasts by measuring the phosphorylation of the myristoylated alanine-rich C kinase substrate and the induction of c-fos transcription following treatment with 200 nM phorbol 12-myristate 13-acetate. At the concentration of 60 μM adriamycin, the phosphorylation of myristoylated alanine-rich C kinase substrate was not inhibited, but the expression of c-fos was completely inhibited. The inhibition of c-fos expression was not specifically mediated via kinase C, since both total RNA synthesis as measured by [3H]-uridine uptake and the fraction of serum-induced c-fos expression that was not attributable to kinase C activity were inhibited by adriamycin. The present data do not support the hypothesis that the cytotoxic effect of adriamycin is attributable to the inhibition of kinase C in vivo. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
27 |
| 終了ページ |
|
|
終了ページ |
34 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 22,
号 1,
p. 27-34,
発行日 1997-03
|
AA0050842X-19970300-0027.pdf (1.2 MB)
