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β-adrenergic stimulation can induce ST-segment elevation without evolution of left ventricular dilation or myocardial ischemia one month after myocardial infarction
https://kindai.repo.nii.ac.jp/records/2002980
https://kindai.repo.nii.ac.jp/records/2002980e51b3483-910f-4453-a50f-10b7c3aec237
| 名前 / ファイル | ライセンス | アクション |
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AA0050842X-19970300-0001.pdf (989.2 KB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||||
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| 公開日 | 2025-06-23 | |||||||||||
| タイトル | ||||||||||||
| タイトル | β-adrenergic stimulation can induce ST-segment elevation without evolution of left ventricular dilation or myocardial ischemia one month after myocardial infarction | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Miyazaki, Toshio
× Miyazaki, Toshio
× Yamamoto, Tadahiko
× Katori, Ryo
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| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | myocardial infarction, ST-segment elevation, isoproterenol, stress test | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Background Recent studies have shown that β-adrenergic stimulation can induce ST-segment elevation similar to exercise, after myocardial infarction. However, how enhanced β-adrenergic activity attributes to ST-segment elevation is unknown. The purpose of the present study was to examine the mechanism of ST-segment elevation as measured by left ventricular function during β-adrenergic stimulation. Methods Subjects comprised 13 patients (12 men, 55±10 years) with first documented anterior myocardial infarction with single vessel disease of the left anterior descending artery elapsed one month after onset. The patients underwent coronary angiograms followed by digital subtraction left ventriculograms before and during isoproterenol infusion. Left ventricular volume, ejection fraction, and asynergic extent as measured by the centerline method were analyzed. Results Isoproterenol induced ST-segment elevation (ΔΣST V2,3,4 6.2±3.5 mm, p<0.01) along with decreased left ventricular volume index both at end-diastole (75.8±18.4 to 59.2±11.5 ml･m⁻², p<0.01) and at end-systole (42.6±16.5 to 28.7±12.0 ml･m⁻², p<0.01), and improved ejection fraction (45.1±8.8 to 53.4±12.7%, p<0.01) and asynergic extent (38.6±20.4 to 30.6±18.6%, p<0.01). The magnitude of the ST-segment elevations positively correlated to left ventricular volume and asynergic extent, and negatively to ejection fraction both before and during stress. Moreover, the magnitude of ST-elevations correlated to decreases in left ventricular volume during stress, indicating that the more left ventricular volumes were decreased the more pronounced ST-segment elevations were induced. Conclusions ST-segment elevation during β-adrenergic stimulation is accompanied by a significant decrease in left ventricular volume and an improvement in both regional and global function during stress even though left ventricular function is severely impaired. Such favorable responses do not connect the ST-elevation to deterioration of wall motion abnormalities or myocardial ischemia. Improved function of both normal and adjacent territories to the infarction suggests that an enhanced sensitivity to β-adrenergic stimulation in the noninfarcted territory may attribute to stress-induced ST-segment elevation after myocardial infarction. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||||
| 言語 | en | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 03866092 | |||||||||||
| 開始ページ | ||||||||||||
| 開始ページ | 1 | |||||||||||
| 終了ページ | ||||||||||||
| 終了ページ | 10 | |||||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 22, 号 1, p. 1-10, 発行日 1997-03 |
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