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Expression of P-glycoprotein in non-recurrent and recurrent breast cancer : Predicting the chemosensitivity and prognosis of breast cancer
https://kindai.repo.nii.ac.jp/records/2002974
https://kindai.repo.nii.ac.jp/records/2002974906e662e-c7ca-4e76-ad95-547d5b818272
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19981200-0057.pdf (674.1 KB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||||||
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| 公開日 | 2025-06-20 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Expression of P-glycoprotein in non-recurrent and recurrent breast cancer : Predicting the chemosensitivity and prognosis of breast cancer | |||||||||||||
| 言語 | en | |||||||||||||
| 作成者 |
Nishi, Kosaku
× Nishi, Kosaku
× Hashimoto, Yukihiko
× Nishimura, Keisuke
× Watatani, Masahiro
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| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | P-glycoprotein, recurrent and non-recurrent breast cancer, primary foci, recurrent foci, immunostaining | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | The expression of P-glycoprotein (Pgp) was immunohistochemically examined using two monoclonal antibodies (JSB-1, C-219) in 27 patients with stages I and II non-recurrent breast cancer and in the primary and recurrent foci of 25 patients with stage I and II recurrent breast cancer. When Pgp was detected by these two antibodies, a strong positivity of Pgp expression was found in 30% of the patients with non-recurrent breast cencer, and in 64% in both the primary and recurrent foci of the 25 patients with recurrent cancer. The frequency of a strong positive Pgp expression in the primary foci was significantly higher in the patients with recurrent breast cancers. Pgp expression was strongly positive in 14% of the 14 patients with non-recurrent breast cancers measuring more than 2cm in size, while expression was strongly positive in 67% of the 18 patients with recurrent breast cancers measuring more than 2cm in size, showing a significant correlation. It is important to examine Pgp expression particularly in the primary foci of breast cancer tumors more than 2cm in size not only for prognosis but also for drug selection. | |||||||||||||
| 言語 | en | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||||||
| 言語 | en | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 03866092 | |||||||||||||
| 開始ページ | ||||||||||||||
| 開始ページ | 57 | |||||||||||||
| 終了ページ | ||||||||||||||
| 終了ページ | 64 | |||||||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 23, 号 3/4, p. 57-64, 発行日 1998-12 |
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