| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-06-20 |
| タイトル |
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|
タイトル |
NK cell and CTL activities during rejection and Graft-Versus-Host Disease following fully allogeneic small bowel transplantation in rats |
|
言語 |
en |
| 作成者 |
Kawabe, Takashi
Nakai, Takuya
Okuno, Kiyotaka
Shindo, Katsuhisa
|
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題 |
rat, small bowel transplantation, rejection, GVHD, NK, CTL |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Background : Rejection and graft-versus-host disease (GVHD) are observed following fully allogeneic small bowel transplantation. However, the immunologic mechanisms responsible for GVHD are still unclear. Methods : Fully allogeneic orthotopic small bowel transplantation from Brown-Norway to Lewis rats were performed using a semi-cuff technique. Signs of rejection and GVHD and host survival time following FK506 administration were recorded. Natural killer (NK) cell activity and CD8+ T-cell activation (CTL activity) in the liver, spleen and mesenteric lymph node (MLN) of the host and MLN of the graft were measured. Results : Rats not given FK506 developed acute rejection. Rats given FK506 at a dose of 0.5 mg/kg/day developed temporary GVHD without evidence of rejection and survived more than 100 days. Rats given 1.0 mg/kg/day of FK506 did not develop GVHD. However, some of them developed chronic rejection and died within 84 days. Immunologic analysis demonstrated that acute rejection occurred in rats that showed high levels of NK and CTL activities, and that temporary GVHD occurred when the NK activity was greater than the CTL activity. These activities were greater in the liver and the graft MLN than in other organs examined. Conclusions : Although FK506 suppresses both NK and CTL activities, different doses of the agent result in different immunosuppressive effects. GVHD and rejection after fully allogeneic small bowel transplantation occur depending on NK and CTL activities. |
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言語 |
en |
| 出版者 |
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|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03866092 |
| 開始ページ |
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開始ページ |
23 |
| 終了ページ |
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終了ページ |
29 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 23,
号 1/2,
p. 23-29,
発行日 1998-06
|
AA0050842X-19980600-0023.pdf (599.9 KB)
