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Superoxide dismutase and nitric oxide synthase activities in SHRSP cerebral cortex and hippocampus
https://kindai.repo.nii.ac.jp/records/2002960
https://kindai.repo.nii.ac.jp/records/20029606ef33391-8137-4426-aa37-a5d287099a3a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19991200-0059.pdf (436.7 KB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||||||||
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| 公開日 | 2025-06-18 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Superoxide dismutase and nitric oxide synthase activities in SHRSP cerebral cortex and hippocampus | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
Kimoto-Kinoshita, Saori
× Kimoto-Kinoshita, Saori
× Nishida, Shozo
× Haga, Hisae
× Irimajiri, Kiyohiro
× Tomura, Takanori T
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| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | SHRSP, superoxide dismutase, nitric oxide synthase, brain | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Mn-, Cu/Zn-superoxide dismutase (SOD) and constitutive type of nitric oxide synthase (NOS) activities in the brain were determined in stroke-prone spontaneously hypertensive rats (SHRSP). Results were compared to Wistar Kyoto rats (WKY) to determine the levels of protection against oxidative stress. In the hippocampus, Mn-, and Cu/Zn-SOD activities in 31-week-old SHRSP were significantly lower than in 15-week-old or WKY. NOS activity in the hippocampus showed no difference between SHRSP and WKY. In the 31-week-old SHRSP cerebral cortex, cerebral injuries occurred and the activities of Mn- and Cu/Zn-SOD and NOS were significantly lower than in 15-week-old or WKY. These observations indicated that hypertensive vascular disease observed in the SHRSP cerebral cortex was a result of decreased antioxidant capacity which is closely associated with the development of stroke and, in turn, shortened life span. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||||||||
| 言語 | en | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 03866092 | |||||||||||||||
| 開始ページ | ||||||||||||||||
| 開始ページ | 59 | |||||||||||||||
| 終了ページ | ||||||||||||||||
| 終了ページ | 63 | |||||||||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 24, 号 3/4, p. 59-63, 発行日 1999-12 |
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