| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-06-18 |
| タイトル |
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|
タイトル |
Superoxide dismutase and nitric oxide synthase activities in SHRSP cerebral cortex and hippocampus |
|
言語 |
en |
| 作成者 |
Kimoto-Kinoshita, Saori
Nishida, Shozo
Haga, Hisae
Irimajiri, Kiyohiro
Tomura, Takanori T
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
SHRSP, superoxide dismutase, nitric oxide synthase, brain |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Mn-, Cu/Zn-superoxide dismutase (SOD) and constitutive type of nitric oxide synthase (NOS) activities in the brain were determined in stroke-prone spontaneously hypertensive rats (SHRSP). Results were compared to Wistar Kyoto rats (WKY) to determine the levels of protection against oxidative stress. In the hippocampus, Mn-, and Cu/Zn-SOD activities in 31-week-old SHRSP were significantly lower than in 15-week-old or WKY. NOS activity in the hippocampus showed no difference between SHRSP and WKY. In the 31-week-old SHRSP cerebral cortex, cerebral injuries occurred and the activities of Mn- and Cu/Zn-SOD and NOS were significantly lower than in 15-week-old or WKY. These observations indicated that hypertensive vascular disease observed in the SHRSP cerebral cortex was a result of decreased antioxidant capacity which is closely associated with the development of stroke and, in turn, shortened life span. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
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|
開始ページ |
59 |
| 終了ページ |
|
|
終了ページ |
63 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 24,
号 3/4,
p. 59-63,
発行日 1999-12
|
AA0050842X-19991200-0059.pdf (436.7 KB)
