WEKO3
アイテム
Physiological and pathological remodeling of vascular matrix by matrix metalloproteinases
https://kindai.repo.nii.ac.jp/records/2002958
https://kindai.repo.nii.ac.jp/records/2002958afd7e22a-8318-423d-a1f9-fa7192d2b915
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19991200-0045.pdf (987.5 KB)
|
|
| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-06-18 | |||||||
| タイトル | ||||||||
| タイトル | Physiological and pathological remodeling of vascular matrix by matrix metalloproteinases | |||||||
| 言語 | en | |||||||
| 作成者 |
Zorina S. Galis, Ph.D
× Zorina S. Galis, Ph.D
|
|||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Reshaping of blood vessels is necessary during physiological adaptation and repair triggered by abnormal hemodynamic conditions and other types of vascular injury. We believe that such response, when carried out too far, leads to the major pathological conditions which affect the blood vessels : atherosclerosis, hypertension, vein graft failure, and restenosis following surgical interventions. The capacity of tissue to change shape depends largely on its capacity to break-down the extracellular matrix scaffold which holds it together. While the capacity of transformed cells to change the morphology of tissues has been long recognized and studied, more recently, we and others have begun to question the intrinsic remodeling capacity of blood vessels. We identified circumstances under which cells that populate normal and diseased blood vessels degrade the extracellular matrix through production of specialized enzymes, called matrix metalloproteinases (MMPs). In a series of studies, we examined the contribution of MMPs and the potential regulatory mechanisms in different vascular pathologies. We started from the premise that vascular MMPs may be modulated by factors which have been characteristically associated with such conditions. During the last few years, active research from our and other laboratories revealed that the action of these enzymes is associated with most all processes known to participate in physiological and pathological remodeling of blood vessels. Understanding the factors which control vascular remodeling will help future design of strategies which would allow or promote the necessary and beneficial blood vessel remodeling, while preventing or limiting the excessive matrix destruction that has pathological consequences. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 45 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 53 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 24, 号 3/4, p. 45-53, 発行日 1999-12 |
|||||||
