| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-06-18 |
| タイトル |
|
|
タイトル |
Morphological study on alveolar damage due to NO2 inhalation in aging rats |
|
言語 |
en |
| 作成者 |
Shimoto, Takashi
Maekura, Shunji
Hashimoto, Shigeo
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
NO2, inhalation, morphology, lung, aging, rat |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The purpose of this experiment was to clarify morphologically the differences in alveolar damage due to NO2 inhalation between young and old rats. Three- and 85-week-old rats were used in the experiment. The animals were exposed to 15 ppm NO2 continuously for 18 days. The lung tissue was examined chronologically by both light and transmission electron microscope. In old rats, alveolar edema was observed clearly 4 days after initial exposure. At seven days after exposure, the alveolar edema had disappeared, but marked interstitial edema was observed in the vas circumference. In young rats, neither alveolar edema nor interstitial edema were observed during the exposure period. Observation under a transmission electron microscope of old rats 4 days after exposure, showed desquamation from the basal membrane in the alveolar 1 type epithelium, and swelling and vacuolation in the capillary endothelium. In old rats 7 days after exposure, the capillary endothelium showed a decrease in the pinocytotic vesicles and disruption of the tight junction. Desquamation from the basal membrane was not observed in the alveolar 1 type epithelium. In old rats 18 days after exposure, the capillary endothelium showed a decrease in pinocytotic vesicles and bleb formation. The endothelial and epithelial damage was slighter in young rats than in old rats during the exposure period. Our observation has clarified that endothelial damage continued during exposure, and that endothelial cells are more sensitive to NO2 damage in aged rats, resulting in edema and interstitial fibrosis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
27 |
| 終了ページ |
|
|
終了ページ |
35 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 24,
号 1/2,
p. 27-35,
発行日 1999-06
|
AA0050842X-19990600-0027.pdf (1.4 MB)
