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Cell-specific localization of human very low density lipoprotein receptor revealed by using novel monoclonal antibodies
https://kindai.repo.nii.ac.jp/records/2002947
https://kindai.repo.nii.ac.jp/records/2002947115271d1-940a-4de2-928d-94d0bb854f0c
| 名前 / ファイル | ライセンス | アクション |
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AA0050842X-20001200-0061.pdf (1.1 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-06-16 | |||||||
| タイトル | ||||||||
| タイトル | Cell-specific localization of human very low density lipoprotein receptor revealed by using novel monoclonal antibodies | |||||||
| 言語 | en | |||||||
| 作成者 |
Fujihara, Ikuya
× Fujihara, Ikuya
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | very low density lipoprotein, very low density lipoprotein receptor, monoclonal antibody, macrophage, neuron, ganglion cell | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Background : Very low density lipoprotein receptor is a new member of the low density lipoprotein receptor gene family, and tissue distribution of its message differs from that of the well-characterized low density lipoprotein receptor. The distribution of very low density lipoprotein receptor at a cellular level has not been thoroughly examined. Methods : Monoclonal antibodies were established from mice immunized with a synthetic peptide that represents an amino-terminal portion of human very low density lipoprotein receptor. These antibodies were used for immunohistochemical staining of various human tissues. Results : The newly established monoclonal antibodies distinguished very low density lipoprotein receptor from low density lipoprotein receptor. Strong immunoreactivity for the very low density lipoprotein receptor was localized in alveolar macrophages, foam cells in atheromatous plaques, central nervous system neurons, and autonomic nerve ganglion cells of the intestinal tract. Conclusions : Very low density lipoprotein receptor may play physiological roles in the uptake of lipoproteins from plasma and tissue fluids and in maintaining functions of neuronal cells. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 61 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 68 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 25, 号 3/4, p. 61-68, 発行日 2000-12 |
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