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Enhancement of midazolam antinociceptive effect by diltiazem in spinal cord of rats
https://kindai.repo.nii.ac.jp/records/2002942
https://kindai.repo.nii.ac.jp/records/2002942ab71fa89-f752-415b-8685-628bf4807541
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-20000600-0037.pdf (446.1 KB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||||||||
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| 公開日 | 2025-06-16 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Enhancement of midazolam antinociceptive effect by diltiazem in spinal cord of rats | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
Yamazumi, Isao
× Yamazumi, Isao
× Okuda, Takahiko
× Wakita, Katsutoshi
× Tsuchiya, Norio
× Koga, Yoshihisa
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| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | midazolam, diltiazem, spinal dorsal horn neuron, nociceptive response, flumazenil | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | The antinociceptive effects of intrathecal coadministrations of midazolam (benzodiazepines) and diltiazem (calcium channel blockers) were investigated in rats. Antinociceptive effects were assessed with the tail-flick test. Although higher intrathecal doses 30μg of midazolam produced an antinociceptive effect, 10μg did not affect the noxious response. When similarly administered, diltiazem alone (100 or 200μg) did not produce an antinociceptive effect. However, concomitant administrations of noneffective doses of midazolam (10μg) and diltiazem (200μg) elicited significant suppressive effects on the thermonociceptive response. Furthermore, this suppressive action by noneffective doses of midazolam and diltiazem was significantly reversed by the benzodiazepine antagonist flumazenil (20μg). It is therefore considered that diltiazem may significantly elicite the antinociceptive effect of midazolam. These findings suggest that the calcium channel plays an important role in the antinociceptive effects of midazolam. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||||||||
| 言語 | en | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 03866092 | |||||||||||||||
| 開始ページ | ||||||||||||||||
| 開始ページ | 37 | |||||||||||||||
| 終了ページ | ||||||||||||||||
| 終了ページ | 42 | |||||||||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 25, 号 1/2, p. 37-42, 発行日 2000-06 |
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