| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-06-12 |
| タイトル |
|
|
タイトル |
Influence of troglitazone, a thiazolidinedione, on chemokine production in colonic epithelial cells |
|
言語 |
en |
| 作成者 |
Hirota, Noriyuki
Ohno, Yasuhiro
Aoki, Norihiko
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
inflammatory bowel diseases, cytokines, troglitazone, peroxisome proliferator activated receptor-gamma, Caco-2 cell |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Inflammatory bowel diseases (IBDs) are chronic and refractory disorders of unknown etiology. Their entity is generally regarded as an uncontrollably increased non-specific inflammatory reaction in the intestinal tract. Among inflammatory mediators, cytokines have particularly important pathophysiological roles in IBDs and tissue concentrations of inflammatory cytokines have been correlated with the disease activity. It has been reported that the production of inflammatory cytokines in monocytes, macrophages, and other cells is inhibited through activation of the peroxisome proliferator activated receptor-gamma (PPARγ). In an attempt to clarify the effect of PPARγ on inflammatory reactions in the colon, we investigated how the activation of PPARγ influenced the production of interleukin (IL)-8 and monocyte chemotactic protein (MCP)-1 in Caco-2 cells, a cell line established from human colorectal carcinoma. IL-1β-stimulated the production of IL-8 and MCP-1 by Caco-2 cells. IL-8 production in IL-1β-stimulated Caco-2 cells was significantly suppressed by troglitazone, a PPAR-r ligand, in a dose-dependent manner. The suppressive effect of troglitazone was also observed on IL-1β-stimulated MCP-1 production in Caco-2 cells. These results suggest possible clinical effectiveness of troglitazone in the treatment of IBDs. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
55 |
| 終了ページ |
|
|
終了ページ |
64 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 26,
号 2,
p. 55-64,
発行日 2001-12
|
AA0050842X-20011200-0055.pdf (667.2 KB)
