| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-05-16 |
| タイトル |
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|
タイトル |
Examination of growth promotion factors for smooth muscle cells of hypertrophied bladders in rats following partial outlet obstruction |
|
言語 |
en |
| 作成者 |
Hanai, Tadashi
Matsumoto, Seiji
Yamamoto, Kazuhiko
Munakata, Hiroshi
Kurita, Takashi
|
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題 |
bladder outlet obstruction, cultured smooth muscle cells, growth factors, rat |
| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
It was reported that outlet obstruction increased the bladder weight in comparison with the controls from one week after the obstruction. This increase continued until 20 weeks after the operation ; however, there was no increase from 30 weeks post operation. Pathologically, thickening of the wall (mainly the muscle layer) was seen. Previously we reported that soluble fractions dervided from bladder 3 to14 weeks after outlet obstruction facilitated the proliferation of cultured smooth muscle cells in the bladder of a normal rat. In order to identify the growth factors contained in the soluble fractions, we have added various growth factors to cultured normal bladder smooth muscle cells. Only basic-fibroblast growth factor (b-FGF) facilitated the growth of the smooth muscle cells. Further, using RT-PCR method, we examined which growth factors were expressed in hypertrophied bladder, and found the expression of b-FGF, nerve growth factor (NGF) and transforming growth factor-β (TGF-β). As to the reason why only b-FGF promoted growth of the cells in our study, we have to further examine the characteristics of cultured normal bladder smooth muscle cells and their growth environment. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03866092 |
| 開始ページ |
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|
開始ページ |
47 |
| 終了ページ |
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|
終了ページ |
54 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 28,
号 2,
p. 47-54,
発行日 2003-12
|
AA0050842X-20031200-0047.pdf (740.5 KB)
