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An examination of cancer antigen coagulant cancer antigen-1 (CCA-1) in bladder cancer
https://kindai.repo.nii.ac.jp/records/2002846
https://kindai.repo.nii.ac.jp/records/200284655850e9b-6036-4387-a3a5-85d56b9a67c7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-20030700-0001.pdf (821.1 KB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-05-16 | |||||||
| タイトル | ||||||||
| タイトル | An examination of cancer antigen coagulant cancer antigen-1 (CCA-1) in bladder cancer | |||||||
| 言語 | en | |||||||
| 作成者 |
Uejima, Shigeya
× Uejima, Shigeya
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | CCA-1, bladder cancer, carcinoma in situ of bladder, tumor marker | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The value of coagulant cancer antigen-1 (CCA-1) as a urinary marker of bladder cancer and as an indicator of the prognosis of carcinoma in situ of the bladder (bladder CIS) was examined. CCA-1 was detected in 83.3% of patients with bladder cancer by immunohistochemical staining. It was found in at least 70.0% of patients with any grade or any histopathological stage. The urinary CCA-1 titer was 0.035±0.023 in the bladder cancer group, which was significantly higher than in the normal control group (0.0035 ± 0.002) or in the benign urologic disease group (0.0067 ±0.003). When the mean +3SD for the normal control group (0.0095) was used as the cut-off value for CCA-1, the urinary CCA-1 positive rate was 76.5% in the bladder cancer group versus 15.4% in the benign disease group. Since hematuria was observed in the patients with CCA-1-positive benign diseases, its effect could not be ignored. By immunohistochemically researching of samples from patients with bladder CIS for both CCA-1 and proliferating cell nuclear antigen (PCNA), it became the evidence that patients with tumors positive for both antigens had a 5-year survival rate of 22.2%, while those with tumors negative for either or both of the antigens had a survival rate of 83.3%. There was a significant difference between the two groups. In conclusion, CCA-1 may be a useful urinary marker for bladder cancer and one of the prognostic indicators of bladder CIS. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 1 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 8 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 28, 号 1, p. 1-8, 発行日 2003-07 |
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