WEKO3
アイテム
Alterations in urinary cortisol metabolism in Japanese patients with type 2 diabetes mellitus
https://kindai.repo.nii.ac.jp/records/2002841
https://kindai.repo.nii.ac.jp/records/20028412bb2f835-8505-4ec5-92b1-cd8034d1fac9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-20051200-0085.pdf (593.0 KB)
|
|
| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-05-14 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Alterations in urinary cortisol metabolism in Japanese patients with type 2 diabetes mellitus | |||||||||||||
| 言語 | en | |||||||||||||
| 作成者 |
Endoh, Tatsuji
× Endoh, Tatsuji
× Ohno, Yasuhiro
× Hoshiro, Madoka
× Aoki, Norihiko
|
|||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | 11β-HSD, insulin resistance, 6β-OHF, type 2 DM | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Objective: Urinary cortisol metabolites were measured in type 2 diabetes patients and control subjects to determine whether type 2 diabetes mellitus and obesity are associated with a derangement in cortisol metabolism. Material and methods: Urine sample from 33 patients with type 2 diabetes and 35 control subjects were studied. Six cortisol metabolites were measured in urine collected over a 24 hour period: cortisol (UFF) 6β-hydroxycortisol (6β-OHF), and cortisone (UFE) were measured by high-performance liquid chromatography (HPLC); tetrahydrocortisol (THF), allo-tetrahydrocortisol (allo-THF) and tetrahydrocortisone (THE) were measured by HPLC mass spectrometry/mass spectrometry (LC-MS/MS) Results: Both urinary 6β-OHF and UFE correlated positively with the body mass index (BMI) among diabetics (p<0.005 and P<0.05, respectively), UFF and UFF/UFE ratio did not. The only metabolite to correlate with BMI in the controls was 6β-OHF, and the correlation was weak (p<0.01). The ratio of urinary THF+allo-THF to THE was significantly lower in the diabetic patients than the control subjects. The ratio of urinary THF+allo-THF to THE was negatively correlated with HbA1c in the diabetic patients (p<0.01). Conclusions: Urinary 6β-OHF had the strongest correlation with body mass index in type 2 diabetes mellitus, followed by urinary free cortisone. No correlation was found between urinary free cortisol and body mass index in normal controls, however, the ratio of urinary THF+allo-THF to THE was negatively correlated with HbA1c, suggesting that down-regulation of the conversion of cortisone to cortisol induced by 11β-hydroxysteroid dehydrogenase type 1 might be enhanced in chronic hyperglycemia. If there is such an enhancement, a compensatory mechanism to reduce the generation of cortisol may be at work in diabetes mellitus. | |||||||||||||
| 言語 | en | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||||||
| 言語 | en | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 03866092 | |||||||||||||
| 開始ページ | ||||||||||||||
| 開始ページ | 85 | |||||||||||||
| 終了ページ | ||||||||||||||
| 終了ページ | 92 | |||||||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 30, 号 2, p. 85-92, 発行日 2005-12 |
|||||||||||||
