| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-06-24 |
| タイトル |
|
|
タイトル |
Risk Factors of Moderate or Severe COVID-19 in Kidney Transplant Recipients |
|
言語 |
en |
| 作成者 |
Kikuchi, Takashi
Fukiage, Ken
Kita, Hiroyuki
Fujimoto, Saizo
Toyoda, Shingo
Hashimoto, Mamoru
Sugimoto, Koichi
Mori, Yasunori
Minami, Takafumi
Yoshimura, Kazuhiro
Fujita, Kazutoshi
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
COVID-19, kidney transplantation, vaccine, virus, infection |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: COVID-19, identified in 2019, has significantly impacted healthcare, especially transplant medicine. This study examines COVID-19 in kidney transplant patients, focusing on risk factors of moderate or severe outcomes. Methods: A retrospective analysis was conducted on 43 kidney transplant recipients who contracted COVID-19 between April 2020 and October 2023. Patients were classified into mild (N=29), moderate (N=6), and severe (N=8) groups based on the COVID- 19 treatment guidelines. Clinical characteristics, immunosuppressive regimens, metabolic factors, vaccination status, and disease outcomes were analyzed. Univariate and multivariate logistic regression were performed to identify risk factors of moderate or severe COVID-19. Results: The overall mortality rate was 4%, with a 25% mortality rate in severe cases. In univariate analysis, obesity (OR: 4.69, p=0.04) and diabetes mellitus (OR: 6.25, p=0.01) were significantly associated with an increased risk of moderate or severe COVID-19. In multivariate analysis, while statistical significance was not reached, obesity (OR: 8.50, p=0.08), diabetes mellitus (OR: 5.35, p=0.07), and mTOR inhibitor use (OR: 8.60, p=0.06) showed trends toward an increased risk. Age ≥65 years was not significantly associated with severe COVID-19 (OR: 8.42, p=0.18). Conversely, receiving ≥3 doses of COVID-19 vaccination was significantly associated with a reduced risk of moderate or severe disease (OR: 0.07, p=0.03), highlighting the protective effect of booster vaccinations. Conclusion: Diabetes mellitus, obesity, and mTOR inhibitor use may contribute to severe COVID-19 in kidney transplant recipients, necessitating proactive monitoring and immunosuppressive management. Booster vaccinations play a crucial role in reducing disease severity in this high-risk population. Early intervention strategies, including optimizing metabolic control and immunosuppressive therapy, should be prioritized to improve patient outcomes. Further large-scale studies are warranted to confirm these findings. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kindai University Medical Association |
|
言語 |
en |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| ID登録 |
|
|
ID登録 |
10.15100/0002002786 |
|
ID登録タイプ |
JaLC |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24327166 |
| 開始ページ |
|
|
開始ページ |
1 |
| 終了ページ |
|
|
終了ページ |
8 |
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY
巻 50,
号 1,
p. 1-8,
発行日 2025-06
|
AA0050842X-20250600-0001.pdf (722 KB)
