| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-04-16 |
| タイトル |
|
|
タイトル |
Strategy for connective tissue diseases from viewpoint of vascular endothelial damage |
|
言語 |
en |
| 作成者 |
Funauchi, Masanori
Kishimoto, Kazuya
Shimazu, Hideki
Tamaki, Chise
Yamagata, Toshiaki
Nozaki, Yuji
Sugiyama, Masafumi
Ikoma, Shinya
Kinoshita, Koji
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
connective tissue diseases, interstitial pneumonitis, vascular endothelial damage, vasoconstrictive agents, transforming growth factor-β, endothelin |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Although prognosis of connective tissue diseases has been much improved by use of corticosteroids and immunosuppressants, resistant cases still exist with dysfunction of various organs. Especially, interstitial pneumonitis (IP) and pulmonary fibrosis are important causes of death in connective tissue diseases such as systemic sclerosis, polymyositis and dermatomyositis. Dysregulation of cytokine and chemokine production, production of vasoconstrictive agents, and apoptosis of fibroblasts are involved in tissue fibrosis. Recently, it has been reported that blood levels of various mediators such as transforming growth factor-β and endothelin that enhance fibrotic changes of various organs are increased in these diseases. On the other hand, vasculitis or endothelial damage is often seen in connective tissue diseases. Vascular endothelial cells produce endothelin that is one of the most intense inducers for fibrosis. Here, IP in the pathogenesis of connective tissue diseases and the relation between vascular endothelial damage and IP is reviewed, and a new strategy for the treatment of connective tissue diseases from viewpoint where an improvement of vascular damage is effective for the treatment of connective tissue diseases is discussed. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
1 |
| 終了ページ |
|
|
終了ページ |
7 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 32,
号 1,
p. 1-7,
発行日 2007-06
|
AA0050842X-20070600-0001.pdf (515.0 KB)
