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アイテム
SLEモデルマウス脾細胞DNAの抗原性と紫外線障害DNAの修復
https://kindai.repo.nii.ac.jp/records/2002663
https://kindai.repo.nii.ac.jp/records/200266330417c80-b193-4f83-a57f-aec8bfbbadb4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19901225-0473.pdf (813.4 KB)
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| アイテムタイプ | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-03-27 | |||||||||
| タイトル | ||||||||||
| タイトル | SLEモデルマウス脾細胞DNAの抗原性と紫外線障害DNAの修復 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Antigenicity and repair of ultraviolet damaged DNA on SLE model mice spleen cells | |||||||||
| 言語 | en | |||||||||
| 著者 |
山添, 康
× 山添, 康
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | SLE, B/W F_1 mouse, spleen cell, anti-DNA antibody, DNA antigenicity, ultraviolet radiation, DNA repair | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 15, 号 4, p. 473-483, 発行日 1990-12-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | New Zealand Black × New Zealand White F_1 hybrid mouse (B/W F_1) is a murine model of systemic lupus erythematosus (SLE). Humans and this mouse with SLE, have anti-DNA antibodies, and show an abnormal response to ultraviolet (UV) radiation. We examined the antigenicity of DNA to determine the origin of anti-DNA antibodies and the speed of repair of the UV damaged DNA. DNA was extracted from spleen cells of B/W F_1 and BALB/c (control) mice. Antigenicity of DNA was determined by ELISA. No significant difference in antigenicity of the DNA was found between B/W F_1 and control mice. The ability to repair UV damaged DNA was determined by measurement of priming ability. UV damaged DNA was repaired more rapidly in B/W F_1 mice than in control mice. In conclusion, the DNA from B/W F_1-spleen cells has no particular antigenicity, but UV-induced DNA was repaired more rapidly in B/W F_1 mice. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
