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アイテム
エンドトキシンの低酸素性肺血管収縮反応への作用
https://kindai.repo.nii.ac.jp/records/2002629
https://kindai.repo.nii.ac.jp/records/2002629edfc45b0-3d4c-4d51-8a8a-48666c5413ab
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19910625-0309.pdf (910.6 KB)
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| アイテムタイプ | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-03-24 | |||||||||
| タイトル | ||||||||||
| タイトル | エンドトキシンの低酸素性肺血管収縮反応への作用 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Effects of endotoxin on hypoxic pulmonary vasoconstriction in dogs | |||||||||
| 言語 | en | |||||||||
| 著者 |
塩川, 泰啓
× 塩川, 泰啓
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | hypoxic pulmonary vasoconstriction, pulmonary circulation, endotoxin, cyclooxygenase inhibitor, ibuprofen | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 16, 号 2, p. 309-323, 発行日 1991-06-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Loss of hypoxic pulmonary vasoconstriction (HPV) response might cause hypoxemia in an acute lung injury such as ARDS. The inhibitory effect of cyclooxygenase pathway products on the HPV response induced by the low-dose endotoxin was examined in dogs. The HPV response was investigated by measuring %Q_<LLL> (ratio of the left lower lobe blood flow to the total pulmonary blood flow), P_ao_2 and the pressure-flow curve of the left lower lobe pulmonary vasculature. An endotoxin-induced increase in %Q_<LLL> with the hypoxic gas ventilation was prevented by ibuprofen pretreatment. The increase in %Q_<LLL> was from 3.7±0.7(%) to 15.8±1.0 and was significant, and the decrease was from 4.8±0.6 to 3.1±0.5. Findings of P_ao_2 and the pressure-flow curve indicated the same HPV inhibition. An endotoxin-induced increase in 6-keto-PGF_1α was blocked by ibuprofen pretreatment. The expected increase in 6-keto-PGF_1α was from 175.5±27.1 (pg/ml) to 332.8±84.1. The block reduced the value from 187.3±37.7 to 217.2±60.4. Decrease in leucocytes counts after endotoxin infusion was observed both in the groups of presence and absence of ibuprofen. These results suggested that prostacyclin release involved with the HPV response inhibition by endotoxin. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
