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表皮角化細胞におけるTransforming Growth Factor-αおよびβ_1によるInterleukin-6産生調節機構の解明
https://kindai.repo.nii.ac.jp/records/2002628
https://kindai.repo.nii.ac.jp/records/2002628e46d6e1c-ba33-40b7-a2ca-e21c9298ba1f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19910625-0299.pdf (1.3 MB)
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| アイテムタイプ | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-03-24 | |||||||||
| タイトル | ||||||||||
| タイトル | 表皮角化細胞におけるTransforming Growth Factor-αおよびβ_1によるInterleukin-6産生調節機構の解明 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Analysis for the regulatory mechanism of Interleukin-6 by Transforming Growth Factor-α and β_1 in epidermal keratinocytes | |||||||||
| 言語 | en | |||||||||
| 著者 |
荒金, 兆典
× 荒金, 兆典
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | Interleukin-6, Transforming growth factor-α, Transforming growth factor-β1, human keratinocyte, molecular regulation | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 16, 号 2, p. 299-308, 発行日 1991-06-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The regulatory mechanism of Interleukin-6 (IL-6) production in cultured human keratinocytes in the presence of the Transforming growth factor (TGF)-α and β1 was examined by determining the amounts of both IL-6 messenger RNA (mRNA) and protein. Normal human epidermal keratinocytes and cells of human trichilemmoma cell line were used. Proliferation of normal human epidermal keratinocytes was stimulated by TGF-α, but inhibited by TGF-β1. Proliferation of cells of human trichilemmoma cell line was not affected by either TGF-α or TGF-β1. In the Northern blot analysis with IL-6 complementary DNA probe, expression of IL-6 mRNA in cells of human trichilemmoma cell line reached the peak 24-48 h after addition of both TGF-α, β1 in the presence of 10% fetal calf serum (FCS). However, in the presence of 1% FCS, the plateau of IL-6 mRNA shifted to an early phase by the addition of TGF-β1. In the enzyme labeled immunosorbent assay with IL-6 monoclonal antibody, IL-6 secretion by cells of human trichilemmoma cell line was upregulated in the presence of TGF-α and β1. These findings indicate that TGF-α and β1 upregulate the expression of IL-6 mRNA and protein. We assume that a cytokine network exists in the epidermis and participates in cell proliferation, wound healing and various other biological responses. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
