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胆汁中ビリルビン分画に影響を及ぼす因子について：特にUDPGA供給状態からみた胆汁中ビリルビン分画の変化
https://kindai.repo.nii.ac.jp/records/2002618
https://kindai.repo.nii.ac.jp/records/200261811fa064a-7644-44a3-b3ad-4545d7f6f9ff
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19910325-0179.pdf (668.9 KB)
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| アイテムタイプ | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-03-19 | |||||||||
| タイトル | ||||||||||
| タイトル | 胆汁中ビリルビン分画に影響を及ぼす因子について：特にUDPGA供給状態からみた胆汁中ビリルビン分画の変化 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Factors influencing the composition of biliary bilirubin glucuronides : Especially in relation to hepatic UDP-glucuronic acid supply | |||||||||
| 言語 | en | |||||||||
| 著者 |
上硲, 俊法
× 上硲, 俊法
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | bilirubin, bile, salicylamide, portal vein, UDP-glucuronic acid, hepatolithiasis | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 16, 号 1, p. 179-189, 発行日 1991-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Factors influencing the composition of biilary bilirubin glucuronides were investigated in humans and rats. In various strains of rats, lower bilirubin [UDP]-glucuronyltransferase activity [BGT] was accompanied by lower biliary [BDG] and higher [BMG] levels and C_8-BMG/C_<12>-BMG ratio. When salicylamide was administered to rats intraperitoneally, hepatic UDP-glucuronic acid [UDPGA] decreased markedly accompanied by a decrease in BDG and increase in the BMG and C_8-BMG/C_<12>-BMG ratio in bile. In portal vein occluded [PO] SD rats, hepatic UDPGA level and biliary BDG were decreased. However, the C_8-BMG/C_<12>-BMG ratio was not changed by PO. These results suggest that the hepatic UDPGA level along with BGT activity mainly detemine the composition of biliary bilirubin glucuronides. Some other factors may influence the biliary C_8-BMG/C_<12>-BMG ratio as shown in the PO rats. In patients with gallstones, the composition of biliary bilirubin conjugates was analyzed. Lower diconjugated bilirubin and higher mono-conjugated bilirubin and unconjugated bilirubin were found in hepatolithiasis compared with these in cholecystolithiasis, suggesting that bile in hepatolithias has higher lithogenicity than cholecystolithiasis. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
