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ラット類洞側ならびに細胆管側肝細胞膜における流動性と脂質組成の比較検討
https://kindai.repo.nii.ac.jp/records/2002615
https://kindai.repo.nii.ac.jp/records/200261531b82c95-bc6a-4711-872b-e4b976b5bd10
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19910325-0139.pdf (609.9 KB)
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| アイテムタイプ | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-03-19 | |||||||||
| タイトル | ||||||||||
| タイトル | ラット類洞側ならびに細胆管側肝細胞膜における流動性と脂質組成の比較検討 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Membrane fluidity and membrane lipid composition in rat liver sinusoidal and canalicular membrane vesicles | |||||||||
| 言語 | en | |||||||||
| 著者 |
胡桃, 良章
× 胡桃, 良章
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | membrane fluidity, sinusoidal membrane vesicles, canalicular membrane vesicles, membrane phospholipid, electron spin resonance, fluorescence polarization, S-adenosyl-L-methionine | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 16, 号 1, p. 139-148, 発行日 1991-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Membrane fluidity and phospholipid composition of sinusoidal membrane vesicles [SMV] and canalicular membrane vesicles [CMV] of rat hepatocytes were studied to investigate their relevance to the topological difference in membrane function. Membrane fluidity was measured by fluorescence polarization of 1,6-diphenyl-1,3,5-hexatrien [DPH] and by the spin label method using 5-doxyl stearic acid [5-DSA] and 16-doxyl stearic acid [16-DSA] as probes. Fluidity of CMV was significantly lower than that of SMV in the both methods. CMV had a significantly higher total phospholipid content than SMV. Phospholipid composition was determined by a newly developed high performance liquid chromatography [HPLC]. The level of sphingomyelin was significantly higher and the level of phosphatidylcholine lower in CMV than SMV. The cholesterol level was significantly higher in CMV than in SMV. These alterations of lipid composition in CMV are considered to be related to the decrease in fluidity. Addition of S-adenosyl-L-methionine [SAMe], which is reported to improve cholestasis, to SMV resulted in an increase in fluidity and Na^+, K^+-ATPase activity. These changes may contribute to the choleretic effect of SAMe. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
