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気管支喘息におけるムスカリン性アセチルコリン受容体に関する臨床的および実験的検討
https://kindai.repo.nii.ac.jp/records/2002608
https://kindai.repo.nii.ac.jp/records/2002608063bede1-a45d-4ced-9703-3cc8bac06b43
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19910325-0043.pdf (1.1 MB)
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| アイテムタイプ | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-03-19 | |||||||||
| タイトル | ||||||||||
| タイトル | 気管支喘息におけるムスカリン性アセチルコリン受容体に関する臨床的および実験的検討 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Clinical and experimental investigation on muscarinic acetylcholine receptor in bronchial asthma | |||||||||
| 言語 | en | |||||||||
| 著者 |
大川, 健太郎
× 大川, 健太郎
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | bronchial asthma, muscarinic acetylcholine receptor, bronchial hyperresponsiveness, Substance P, vasoactive intestinal peptide | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 16, 号 1, p. 43-61, 発行日 1991-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Clinical and experimental studies of bronchial hyperreactivity of asthma were performed with respect to muscarinic acetylcholine receptors (mACh-R). The characteristics of mACh-R in the guinea pig pulmonary tissues and in human lymphocytes were assessed by determining the affinity and density using ^3H-quinuclidinyl benzilate, a potent muscarinic antagonist. Furthermore, the characteristics of guinea pig M1-receptors were evaluated using ^3H-pirenzepine, a selective muscarinic antagonist. Ovalbumine-sensitized guinea pigs and control animals were used, and the influence of some drugs and neuropeptides on mACh-R was also investigated. There was a correlation between mACh-R (Bmax) of human peripheral lymphocytes and bronchial hypersensitivity (Dmin. in asthograph). The density of mACh-R in OA-sensitized guinea pigs (165.3±51.8 fmol/mg prot.) was three times as high as that in the control group (55.1±4.8fmol/mg prot.), and there was no difference between the affinity of the OA-sensitized group and control group The measurement of M1-receptors, revealed that this increase of mACh-R was due to the increase of M2 and other receptors. mACh-R (Bmax) decreased by administration of the beta agonist and muscarinic agonist, but the affinity (Kd) of mACh-R did not change. The density of mACh-R was not changed by administration with glucocorticoids, but Saibokutou (TJ-96) decreased markedly the density of mACh-R. The neuropeptide, Substance P decreased the density of mACh-R whereas the vasoactive intestinal peptide increased it. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
