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肝オルニチン脱炭酸酵素活性からみたラット肝発癌過程での門脈中エンドトキシンの影響
https://kindai.repo.nii.ac.jp/records/2002547
https://kindai.repo.nii.ac.jp/records/20025475f63726d-1983-4ed3-a9df-4c6b8609de2e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19910925-0403.pdf (1.3 MB)
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| アイテムタイプ | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-03-07 | |||||||||
| タイトル | ||||||||||
| タイトル | 肝オルニチン脱炭酸酵素活性からみたラット肝発癌過程での門脈中エンドトキシンの影響 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Influence of portal endotoxin on rat hepatocarcinogenesis determined from hepatic ornithine decarboxylase activity | |||||||||
| 言語 | en | |||||||||
| 著者 |
森下, 明彦
× 森下, 明彦
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | portal endotoxin, hepatic ornithine decarboxylase, rat hepatocarcinogenesis, 2-acetylaminofluorene, hepatic neoplastic nodules, oral antibiotics | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 16, 号 3, p. 403-416, 発行日 1991-09-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | To assess the relationship between the intestinal endotoxin and the development of hepatic carcinoma, 2-acetylaminofluorene (2AAF), a potential carcinogenic agent, was administered to male Wistar rats. In the animals, the portal venous endotoxin concentration (PEt), and the activity of hepatic ornithine decarboxylase (ODC), a marker-enzyme of carcinogenic promotion, were serially determined. Six-week-old rats fed normal diets were divided into two groups ; one group was given water containing antibiotics (AB, polymyxin B 1,000 U/ml plus neomycin 0.35 mg/ml) ad libitum and the other group given tap-water. At 9 weeks old, the two groups were subdivided into the rats given 2AAF and those not given 2AAF. The rat subgroup given AB and 2AAF (AB+2AAF ; n=84) and the other group given only 2AAF (2AAF ; n=84) were mainly studied. From the 7th week following 2AAF-administration, the weekly elevation of PEt (normal range 3.0±1.7 pg/ml, mean±SD) was significantly inhibited in the AB+2AAF group compared with the level in the 2AAF group (0.8±0,4 vs 5.6±1.4 at the 7th week ; p<0.01 and 2.8±0.7 vs 6.7±1.2 at the 12th week ; p<0.05). The weekly elevation of ODC-activity (pmoles 14 CO2/30min/mg protein) in the AB+2AAF group also was significantly inhibited compared with the activity in the 2AAF group (4.9±1.1 vs 22.5±7.4 at the 7th week ; p<0.05 and 1.5±0.6 vs 4.4±0.8 at the 12th week ; p<0.05). Neoplastic nodules arising in liver are thought to be precancerous, and their involvements were more frequent in the 2AAF group than in the AB+2AAF group (p<0.05). These results suggest that PEt may be a promotor affecting the early carcinogenic process of the liver. Oral administration of nonabsorbable antibiotics to reduce PEt may be a possible prophylaxis against the carcinogenesis. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
