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エイコサペンタエン酸は骨格筋の遺伝子発現を変化させ筋クランプ(足のつり)発症を予防する
https://kindai.repo.nii.ac.jp/records/2002525
https://kindai.repo.nii.ac.jp/records/20025258d8b63b7-cf69-40e1-adcb-fc186db03fe1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00064044-20250331-0044.pdf (693.1 KB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||||||||||||||
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| 公開日 | 2025-03-03 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | エイコサペンタエン酸は骨格筋の遺伝子発現を変化させ筋クランプ(足のつり)発症を予防する | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Eicosapentaenoic acid alters gene expression profiles in the skeletal muscle and prevents the incidence of muscle cramps in mouse | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 作成者 |
有本, 明寿香
× 有本, 明寿香
× 井通, 美祈
× 堀井, 鴻佑
× 森島, 真幸
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| 言語 | ||||||||||||||||||||||
| 言語 | jpn | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | muscle cramp, eicosapentaenoic acid, metabolic acidosis | |||||||||||||||||||||
| 内容記述 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Muscle cramps are painful, sudden and involuntary muscle contractions that are generally self-limiting. However, the underlying pathophysiological mechanisms have not been fully elucidated. The objective of this study was to establish a muscle cramp-induced mouse model and to investigate the preventive effect of eicosapentaenoic acid (EPA) on muscle cramps. Male C57BL/6 mice were fed a normal diet with sesame oil, with or without EPA, for six weeks. After four weeks, the muscle cramp group was treated with a vasopressin V₂ receptor antagonist and ammonium chloride. Metabolic acidosis was confirmed by a significant reduction in serum pH and an increase in AQP2 mRNA expression in the kidney of the cramp group. In contrast, EPA administration prevented the decrease in serum pH, increased Akt phosphorylation and shifted MyHC composition toward the slow-twitch muscle fiber type in the soleus muscle. These results suggest that this muscle cramp model may serve as a valuable experimental tool. Furthermore, they indicate that EPA administration may prevent muscle cramps by activating signaling pathways that promote protein synthesis, specifically in slow-twitch muscle fibers. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | 近畿大学農学部 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 21896267 | |||||||||||||||||||||
| 書誌情報 |
ja : 近畿大学農学部紀要 en : MEMOIRS OF THE FACULTY OF AGRICULTURE OF KINDAI UNIVERSITY 号 58, p. 44-57, 発行日 2025-03-31 |
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