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ラット腎糸球体のα_1受容体の性質とその局在
https://kindai.repo.nii.ac.jp/records/2002474
https://kindai.repo.nii.ac.jp/records/200247465ac4779-755d-41b9-a7f9-f8573cb363af
| 名前 / ファイル | ライセンス | アクション |
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AN00063584-19911225-0595.pdf (1.5 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-02-26 | |||||||||
| タイトル | ||||||||||
| タイトル | ラット腎糸球体のα_1受容体の性質とその局在 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Characterization and localization of α_1-adrenergic receptors in rat glomeruli | |||||||||
| 言語 | en | |||||||||
| 著者 |
木野, 博文
× 木野, 博文
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | α_1-adrenergic receptor, mesangial cell, patch clamp, ion channel, M-SHRSP, isolated glomeruli | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 16, 号 4, p. 595-613, 発行日 1991-12-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The localization of α_1-adrenergic receptors in rat renal glomeruli was examined by using the radioligand receptor assay and patch clamp technique. In Sprague-Dawley (SD) rats, there were two different kinds of glomerular α_1-adrenergic receptors, one had high affinity and low binding capacity and another had low affinity and high binding capacity. In the rats exposed to cold stress, glomerular α_1-adrenergic receptors decreased significantly, while the urinary excretion of catecholamines markedly increased. Wister Kyoto rats (WKY) had two distinct affinities of glomerular α_1-adrenergic receptors and did not show any significant changes between the ages of 6 and 10 weeks. On the other hand, the M strain of stroke-prone spontaneously hypertensive rats (M-SHRSP) had only one type of glomerular α_1-adrenergic receptors. However, these affinities in M-SHRSP were quite different between the two ages. For determining the localization of α_1-adrenergic receptors in glomeruli, mesangial cells were cultured from the glomeruli of SD rats. Cultured rat mesangial cells were contracted by phenylephrine, and this contraction was attenuated by the α_1-blocker bunazosin. In the patch clamp experiment, two different conductances of K^+ channels were observed from cultured rat mesangial cells activated by phenylephrine under conditions of inside-out patch. These channels were blocked by Ba^<2+>, which implys that these carriers were K^+ ions. These findings suggest that α_1-adrenergic receptors exist in rat glomeruli and that they are localized in the mesangial cell. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
