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ヒスタミン受容体作用薬のマウスリンパ球抗体産生及びコラーゲン関節炎に対する影響
https://kindai.repo.nii.ac.jp/records/2002472
https://kindai.repo.nii.ac.jp/records/2002472372617e0-39aa-4b39-8470-be16843a3d06
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19911225-0573.pdf (606.5 KB)
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| アイテムタイプ | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-02-26 | |||||||||
| タイトル | ||||||||||
| タイトル | ヒスタミン受容体作用薬のマウスリンパ球抗体産生及びコラーゲン関節炎に対する影響 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | The effects of histamine receptors on IgG production in mice spleen cells and on mice collagen induced arthritis | |||||||||
| 言語 | en | |||||||||
| 著者 |
藤原, 茂樹
× 藤原, 茂樹
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | histamine receptor, collagen-induced arthritis, type II collagen | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 16, 号 4, p. 573-580, 発行日 1991-12-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | This study was carried out to investigate the role of histamine receptors in IgG production by spleen cells and the effects of histaminergic agonists on type II collagen-induced arthritis in mice. Con A-derived IgG production in the spleen cells from normal DBA/1J mice was dose-dependently suppressed by histamine. Moreover, both of histaminergic H_1 and H_2 agonists suppressed Con A-derived IgG production in the normal spleen cells. In CIA mice, spontaneous IgG production in the spleen cells was significantly higher than that in normal mice, but almost no Con A-derived production was observed in the spleen cells. Histamine induced suppression of the spontaneous IgG production in the spleen ceils with CIA was weaker than the histamine-induced suppression on Con A-derived IgG production in the normal spleen cells. The H_2-agonist-induced suppression on the IgG production in the CIA spleen cells was weaker than that in the normal spleen cells. On the other hand. the H_1-agonist-induced suppression on the IgG production in the CIA spleen cells was stronger than that in the normal spleen cells. Both H_1 and H_2 histaminergic agonists suppressed the incidence of onset with arthritis, arthritic index. and the titer of the anti-type II collagen antibody in CIA mice. The H_1 agonist had stronger benefical effects than the H_2 agorist. These findings suggested that both H_1 and H_2 histaminergic agonists had suppressive effects on in vitro IgG production in the spleen cells and also on in vivo disease activity in CIA. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
