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マウスモデルを用いた自家骨髄移植における移植細胞の抗腫瘍効果のin vitroでの解析
https://kindai.repo.nii.ac.jp/records/2002468
https://kindai.repo.nii.ac.jp/records/2002468a686bff4-0bad-4ce7-bdf5-6b82c0de05a4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19911225-0529.pdf (597.4 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-02-26 | |||||||||
| タイトル | ||||||||||
| タイトル | マウスモデルを用いた自家骨髄移植における移植細胞の抗腫瘍効果のin vitroでの解析 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Analysis of antitumor effects of grafts in autologous bone marrow transplantation in vitro | |||||||||
| 言語 | en | |||||||||
| 著者 |
佐藤, 充重
× 佐藤, 充重
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | bone marrow transplantation, G_1 phase cell, IL-3, IL-6, anti-tumor effect | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 16, 号 4, p. 529-539, 発行日 1991-12-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | To clarify the interaction of splenocytes and grafts when grafts are trapped in the spleen after autologous bone marrow transplantation in cancer patients, experiments using mouse cells were conducted in vitro. Female DBA2/Cr mice aged 8 to 9 weeks and tumor cell lines L1210, P388D_1 and K562 were used. After L1210 cells and mouse splenocytes were cultured, mouse non-adherent bone marrow cells were added and culturing was continued. The resulting supernatant was separated from the culture broth (supernatant I). Using supernatant I, non-adherent bone marrow cells were cultured, and the resulting supernatant was collected (supernatant II). Factorial assay revealed that supernatant I contained interleukin-3 and interleukin-6. Each tumor cell line was cultured using supernatant II. Supernatant II was found to contain a species-specific tumor growth suppressor that significantly (P<0.001) suppressed the growth of L1210 cells and P388D_1 cells in comparison with controls, but did not suppress the growth of K562 cells. It is inferred that a similar tumor growth suppressor is also produced when grafts are trapped in the spleen in vivo. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
