{"created":"2025-02-12T07:57:27.642343+00:00","id":2002429,"links":{},"metadata":{"_buckets":{"deposit":"12313df2-d9ca-4425-951b-6d315cb55d8d"},"_deposit":{"created_by":42,"id":"2002429","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2002429"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02002429","sets":["14:923:1477:1739343541763"]},"author_link":[],"control_number":"2002429","item_2_biblio_info_21":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-06-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"321","bibliographicPageStart":"309","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"In this study three proteins with trypsin inhibitory activity were purified to apparent homogeneity from hamster plasma and the changes in their plasma level after acute inflammation were examined. α-1-Antiproteinase had a molecular mass of 68 kDa, and inhibited elastase, trypsin and chymotrypsin but not plasmin, porcine pancreas kallikrein or guinea pig plasma kallikrein. Countertrypin and pre-α-trypsin inhibitor had a molecular mass of 55 kDa and 120 kDa, respectively, and both inhibited only trypsin. The pre-α-trypsin inhibitor consisted of light (25 kDa) and heavy (90 kDa) polypeptide chains, which were dissociated by chondroitinase ABC treatment but not by heating at 100℃ in the presence of sodium dodecyl sulfate and dithiothreitol. Thirteen amino acids of the N-terminal eicosapeptide sequence of both light and heavy chains were identical with the corresponding regions of human serum pre-α-trypsin inhibitor. After induction of inflammation by intraperitoneal injection of Salmonella typhimurium lipopolysaccharide, the plasma level of pre-α-trypsin inhibitor increased and that of murinoglobulin decreased, but other inhibitors showed no significant change.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"雨宮, 修二","creatorNameLang":"ja"},{"creatorName":"Amemiya, Shuji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-19920625-0309.pdf","filesize":[{"value":"686.9 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2002429/files/AN00063584-19920625-0309.pdf"},"version_id":"2a895b8c-6fd7-4d45-a283-7d0b43481e8c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α-1-antiproteinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"countertrypin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pre-α-trypsin inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hamster plasma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"acute phase response","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ハムスター血漿中のプロテイナーゼインヒビター：精製と性質および急性相反応","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ハムスター血漿中のプロテイナーゼインヒビター：精製と性質および急性相反応","subitem_title_language":"ja"},{"subitem_title":"Proteinase inhibitors in hamster plasma : Purification, properties and acute phase response","subitem_title_language":"en"}]},"item_type_id":"2","owner":"42","path":["1739343541763"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-13"},"publish_date":"2025-02-13","publish_status":"0","recid":"2002429","relation_version_is_last":true,"title":["ハムスター血漿中のプロテイナーゼインヒビター：精製と性質および急性相反応"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2025-03-10T01:05:44.102588+00:00"}