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ハムスター血漿中のプロテイナーゼインヒビター：精製と性質および急性相反応
https://kindai.repo.nii.ac.jp/records/2002429
https://kindai.repo.nii.ac.jp/records/20024299f1e2bd8-7275-4713-be5b-51ae075a074c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19920625-0309.pdf (686.9 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-02-13 | |||||||||
| タイトル | ||||||||||
| タイトル | ハムスター血漿中のプロテイナーゼインヒビター：精製と性質および急性相反応 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Proteinase inhibitors in hamster plasma : Purification, properties and acute phase response | |||||||||
| 言語 | en | |||||||||
| 著者 |
雨宮, 修二
× 雨宮, 修二
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | α-1-antiproteinase, countertrypin, pre-α-trypsin inhibitor, hamster plasma, acute phase response, inflammation | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 17, 号 2, p. 309-321, 発行日 1992-06-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | In this study three proteins with trypsin inhibitory activity were purified to apparent homogeneity from hamster plasma and the changes in their plasma level after acute inflammation were examined. α-1-Antiproteinase had a molecular mass of 68 kDa, and inhibited elastase, trypsin and chymotrypsin but not plasmin, porcine pancreas kallikrein or guinea pig plasma kallikrein. Countertrypin and pre-α-trypsin inhibitor had a molecular mass of 55 kDa and 120 kDa, respectively, and both inhibited only trypsin. The pre-α-trypsin inhibitor consisted of light (25 kDa) and heavy (90 kDa) polypeptide chains, which were dissociated by chondroitinase ABC treatment but not by heating at 100℃ in the presence of sodium dodecyl sulfate and dithiothreitol. Thirteen amino acids of the N-terminal eicosapeptide sequence of both light and heavy chains were identical with the corresponding regions of human serum pre-α-trypsin inhibitor. After induction of inflammation by intraperitoneal injection of Salmonella typhimurium lipopolysaccharide, the plasma level of pre-α-trypsin inhibitor increased and that of murinoglobulin decreased, but other inhibitors showed no significant change. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
