WEKO3
アイテム
LAK細胞の細胞傷害活性発現における細胞接着分子の役割
https://kindai.repo.nii.ac.jp/records/2002426
https://kindai.repo.nii.ac.jp/records/2002426119bb089-8c3a-4ab5-a859-e13c37b06edd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19920625-0273.pdf (615.1 KB)
|
|
| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-02-13 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | LAK細胞の細胞傷害活性発現における細胞接着分子の役割 | |||||||||||||
| 言語 | ja | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | The role of cell adhesion molecules on the lymphokine activated killer (LAK) cell activity | |||||||||||||
| 言語 | en | |||||||||||||
| 著者 |
白川, 親
× 白川, 親
× 入交, 清博
|
|||||||||||||
| 言語 | ||||||||||||||
| 言語 | jpn | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | lymphokine activated killer cells (LAK), cell adhesion molecules | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 出版者 名前 | ||||||||||||||
| 出版者 | 近畿大学医学会 | |||||||||||||
| 言語 | ja | |||||||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 17, 号 2, p. 273-281, 発行日 1992-06-25 |
|||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 03858367 | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | The importance of cell adhesion molecules for lymphokine activated killer (LAK) cells, both in their formation of antigen independent binding and in their lysis of target cells were reported. We examined the expression of lymphocyte function associated antigen 1 (LFA-1), intercellular adhesion molecule 1 (ICAM-1), and CD2 on LAK and target cells. Although expression levels of LFA-1 and CD2 on LAK were the same as on T cells and lymphocytes, the target cells and LAK cells showed higher binding formation than the target cells and lymphocytes. The cytolytic activity and binding activity of LAK cells were partially inhibited by treatment with anti-CD2, anti-LFA-1, or anti-ICAM-1Ab, and almost completely inhibited by anti-CD2 and anti-LFA-1Ab in combination. Preincubation of LAK cells with ICAM-1Ab, did not inhibit the cytolytic activity of LAK cells, but preincubation of target cells with anti-ICAM-1Ab did. These studies demonstrated two distinct pathways of LAK cell binding formation of LAK and target cells caused cytotoxicity. The expression of LFA-1 on LAK cells and of ICAM-1 on the target cells were considered to play important roles in the activity of LAK cells. | |||||||||||||
| 言語 | en | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||||||
| 言語 | ja | |||||||||||||
