WEKO3
アイテム
Neuraminidase処理Colon 26結腸癌細胞の門脈内投与による肝転移モデルの作製
https://kindai.repo.nii.ac.jp/records/2002425
https://kindai.repo.nii.ac.jp/records/200242552c65e61-3f3f-4e37-acb2-d65985dfe848
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19920625-0265.pdf (1.0 MB)
|
|
| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-02-13 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Neuraminidase処理Colon 26結腸癌細胞の門脈内投与による肝転移モデルの作製 | |||||||||||||
| 言語 | ja | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Establishment of a quantitative model for liver metastasis in mice with neuraminidase treated colon 26 adenocarcinoma cells via the portal vein | |||||||||||||
| 言語 | en | |||||||||||||
| 著者 |
白山, 泰明
× 白山, 泰明
× 奥野, 清隆
|
|||||||||||||
| 言語 | ||||||||||||||
| 言語 | jpn | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | colon 26 adenocarcinoma, Neuraminidase, Liver metastasis | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 出版者 名前 | ||||||||||||||
| 出版者 | 近畿大学医学会 | |||||||||||||
| 言語 | ja | |||||||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 17, 号 2, p. 265-272, 発行日 1992-06-25 |
|||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 03858367 | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | In this study, a liver metastasis model was established in mice. The in vitro colon 26 cultured cell line was made from an in vivo transplantable colon 26 adenocarcinoma tumor mass by using standard enzymatic treatments (collagenase, DNase). In vitro cultured cells were injected into the portal vein of BALB/c mice for inducing liver metastases after the cells were desialyzed with neuraminidase to promote their uptake into liver cells. Three weeks later, metastatic foci with nontreated colon 26 were found in 50-70% of the mice. By contrast, treated colon 26 cells markedly increased the incidence of hepatic matastases ; countable hapatic colonies were found in all mice (100%). We also confirmed that intravenous injection of galactocerebroside (a competitive inhibitor of D-galactose receptor), prior to intraportal injection, suppressed the liver metastasis of cancer. This results may be related to the liver-characteristic D-galactose receptors since pre-injection with an excess amount of galactocerebroside completely prevented tumor colonization in the liver. This experimental model was found to be useful for the analysis of hepatic metastases from colorectal cancer. | |||||||||||||
| 言語 | en | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||||||
| 言語 | ja | |||||||||||||
