| アイテムタイプ |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2025-02-03 |
| タイトル |
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タイトル |
原発性高コレステロール血症に対するHMG-CoA還元酵素阻害剤(Pravastatin)長期投与の臨床効果 |
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言語 |
ja |
| タイトル |
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タイトル |
Effect of long-term administration of HMG-CoA reductase inhibitor pravastatin, to the patients with primary hypercholesterolemia |
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言語 |
en |
| 著者 |
諏訪, 雅男
上硲, 俊法
足立, 幸彦
山本, 俊夫
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| 言語 |
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言語 |
jpn |
| キーワード |
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主題 |
HMG-CoA reductase inhibitor, primary hypercholesterolemia, HDL cholesterol |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| 出版タイプ |
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|
出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 名前 |
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出版者 |
近畿大学医学会 |
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言語 |
ja |
| bibliographic_information |
ja : 近畿大学医学雑誌
en : Medical Journal of Kinki University
巻 17,
号 4補冊,
p. 73-75,
発行日 1992-12-30
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03858367 |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Pravastation (10 mg/day) was administered to 259 patients with primary hypercholesterolemia for 12 months, and the serum lipid and apoproteins levels were measured. Any side effect were also recorded. The mean total cholesterol level decreased to below 220 mg/dl after 1 month of the treatment and this effect lasted throughout the study. The rate of decrease in total cholesterol level was not different between the age groups. A marked decrease in the LDL cholesterol level was observed, and the rate of its decrease was higher than that of the total cholesterol level. The HDL cholesterol level increased significantly. This increase was remarked especially in the patents with a low pre-administration level of HDL cholesterol or with hypertriglyceridemia. The level of apoprotein A-1 changed similarly to that of HDL cholesterol, the level of apoprotein B similarly to that of LDL cholesterol, and the level of apoprotein E similarly to that of triglgceride. These findings suggested that pravastation increases HDL particles, decreases LDL particles. and improves VLDL metabolism. No significant changes in the loboratory data including CPK and no adverse symptoms were observed. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
本文データはCiNiiから複製したものである。 |
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言語 |
ja |
AN00063584-19921230-0073.pdf (188.7 KB)
