| アイテムタイプ |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2025-02-03 |
| タイトル |
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|
タイトル |
SHRSPの脳底動脈におけるCalcitonin generelated peptideの弛緩作用 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
Relaxant effect of calcitonin gene-related peptide on basilar arteries of SHRSP |
|
言語 |
en |
| 著者 |
西村, 芳卓
鈴木, 有朋
高野, 照起
菱田, 守彦
内田, 隆久
二見, 国彦
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| 言語 |
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|
言語 |
jpn |
| キーワード |
|
|
主題 |
SHRSP, basilar artery, calcitonin gene-related peptide, vasodilator peptide |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 名前 |
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|
出版者 |
近畿大学医学会 |
|
言語 |
ja |
| bibliographic_information |
ja : 近畿大学医学雑誌
en : Medical Journal of Kinki University
巻 17,
号 4補冊,
p. 21-24,
発行日 1992-12-30
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| ISSN |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03858367 |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Relaxant responses to several vasodilator peptides and cyclic AMP-affecting drugs were compared between basilar artery rings isolated from 6-month-old SHRSP and age-matched WKY. Relaxation induced by calcitonin gene-related peptide (CGRP) was markedly higher in SHRSP than in WKY. However, no significant differences were found in the relaxation induced by vasoactive intestinal polypeptide, peptide histidine isoleucine, atrial natriuretic peptide, and brain natriuretic peptide between the two groups. In addition, there were no differences between WKY and SHRSP in the response to forskolin, dibutyryl cyclic AMP, and 3-isobutyl-l-methylxanthine. These findings suggested that the enhanced CGRP-induced relaxation found in SHRSP results from increased sensitivity of CGRP receptors, and that CGRP has a pathophysiological role in the regulation of cerebral circulation in the presence of hypertension. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
本文データはCiNiiから複製したものである。 |
|
言語 |
ja |
AN00063584-19921230-0021.pdf (207.7 KB)
