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W^<sh>/W^<sh>マウスにおけるc-kit癌原遺伝子の細胞種特異的転写異常
https://kindai.repo.nii.ac.jp/records/2002296
https://kindai.repo.nii.ac.jp/records/20022968758184f-cb01-4c20-8920-92b15dbeb6ee
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19921225-0485.pdf (554.5 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-01-22 | |||||||||
| タイトル | ||||||||||
| タイトル | W^<sh>/W^<sh>マウスにおけるc-kit癌原遺伝子の細胞種特異的転写異常 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Cell type specific abnormality of c-kit oncogene transcription in W^<sh>/W^<sh> mice | |||||||||
| 言語 | en | |||||||||
| 著者 |
東野, 年温
× 東野, 年温
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | W^<sh>/W^<sh> mice, c-kit receptor, mast cell, W mutation, cell type specific abnormality | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 17, 号 4, p. 485-495, 発行日 1992-12-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The W^<sh> is a mutant allele at the W (c-kit) locus of mice. Mice of W^<sh>/W^<sh> genotype have white hair and black eyes. Although adult C57BL/6-W^<sh>/W^<sh> mice are not anemic, they showed a marked depletion of mast cells. Most homozygous or double heterozygous mice at the W (c-kit) locus whose mast cell depletion was comparable to that of W^<sh>/W^<sh> mice are sterile due to depletion of germ cells, but male and female W^<sh>/W^<sh> mice have many germ cells in their gonads. We investigated the mechanism of mast cell depletion of W^<sh>/W^<sh> mice. Cultured mast cells (CMC) derived from the spleen of W^<sh>/W^<sh> mice did not attach to normal (+/+) fibroblasts and disappeared within 2 weeks after the initiation of the co-culture. W^<sh>/W^<sh> CMC did not express the extracellular domain of c-kit protein and moreover did not contain c-kit protein. The c-kit mRNA was strongly expressed in +/+ CMC but was not detectable in W^<sh>/W^<sh> CMC. In spite of the lack of c-kit mRNA in W^<sh>/W^<sh> CMC, c-kit mRNA was detectable in the spleen, testis and cerebellum of W^<sh>/W^<sh> mice. No significant changes were found in the coding region of c-kit transcripts obtained from the cerebellum of W^<sh>/W^<sh> mice. Taken together, the expression of the c-kit gene in W^<sh>/W^<sh> mice appeared to be influenced by the type of cell ; it was normal in the cerebellum, weak in the testis and spleen, and not detectable in CMC. The symptoms of C57BL/6-W^<sh>/W^<sh> mice paralleled the expression of c-kit gene. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
