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血管内皮細胞および滑膜線維芽細胞におけるヒスタミン受容体の役割について
https://kindai.repo.nii.ac.jp/records/2002269
https://kindai.repo.nii.ac.jp/records/20022692e81b39a-675e-4ddd-b67b-6c39c0fa878c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19930325-0163.pdf (628.2 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-01-17 | |||||||||
| タイトル | ||||||||||
| タイトル | 血管内皮細胞および滑膜線維芽細胞におけるヒスタミン受容体の役割について | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | The role of histamine receptors in endothelial cells and synovial fibroblastic cells | |||||||||
| 言語 | en | |||||||||
| 著者 |
勝久, 敬太
× 勝久, 敬太
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | endothelial cells, synovial fibroblastic cells, dermal fibroblastic cells, histamine receptors, interleukin-6 | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 18, 号 1, p. 163-175, 発行日 1993-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The effects of histaminergic agonists on the production of interleukin-6 (IL-6) and cell proliferation in endothelial cells and synovial fibroblastic cells were examined. Both histamine and H_1-receptor agonist, 2-pyridylethylamine significantly increased IL-6 production and cell proliferation in both types of cell, while H_2-receptor agonist, dimaprit significantly decreased IL-6 production and cell proliferation in both types of cell. Serum and synovial fluid were obtained from patients with rheumatoid arthritis (RA) or osteoarthritis (OA), and their effects on the production of IL-6 and cell proliferation in endothelial cells and synovial fibroblastic cells were examined. Synovial fluid from RA patients significantly increased these events in both types of cell, without stimulation by histaminergic agonists. In addition, synovial fluid from RA patients suppressed the effects of the H_2-receptor agonist on IL-6 production and cell proliferation both in endothelial cells and synovial fibroblastic cells. These findings indicate that a decrease in the suppressive effects of H_2-histaminergic agonist on IL-6 production and cell proliferation both in endothelial cells and synovial fibroblastic cells's involved in perpetuating the inflammatory process in RA. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
