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ヒト甲状腺におけるIおよびIV型コラーゲン分解酵素活性に関する研究
https://kindai.repo.nii.ac.jp/records/2002265
https://kindai.repo.nii.ac.jp/records/2002265a95f617f-23bd-4960-97da-12525475d6ee
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19930325-0099.pdf (2.3 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2025-01-17 | |||||||||
| タイトル | ||||||||||
| タイトル | ヒト甲状腺におけるIおよびIV型コラーゲン分解酵素活性に関する研究 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Activities of type I and IV collagenase in various diseased tissues of human thyroid | |||||||||
| 言語 | en | |||||||||
| 著者 |
中野, 貴之
× 中野, 貴之
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | thyroid cancer, type I collagenase, type IV collagenase, collagen gel culture, immunostaining | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 18, 号 1, p. 99-117, 発行日 1993-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | To investigate the correlation between collagenase activity and invasion or metastasis of human thyroid cancers, type I and IV collagenase activities were measured using ^3H labeled collagens, and the immunohistochemical observation with anti-type IV collagen antibody and morphological measurement of the dimension of type I collagen dissolved by cultured cancer cells in the type I collagen gel were carried out. In papillary and follicular carcinomas with extracapsular invasion and lymph node metastasis, activities of type I and IV collagenase were higher than those in uninvolved or other diseased thyroid tissues. Moreover, these collagenase activities increased with the advance in the degree of TNM classification. In the immunohistochemical study, type IV collagen was exclusively localized in the basement membrane region of intact thyroid tissues. In thyroid carcinomas, type IV collagen disclosed the marked discontinuity or disappearance in the delineation of basement membranes. Moreover, immunostaining of the type IV collagen severely decreased in the surrounding intact tissue in thyroid carcinoma. In type I collagen gel embedded culture, cancer cells dissolved the surrounding collagens more than intact or other non-cancerous diseased cells. These findings suggested that increased activities of type I and IV collagenase played an important role in local invasion as well as metastasis in thyroid cancers, and also suggested that these collagenase were produced by thyroid cancers themselves. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
