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Wistar Kyotoラットにおけるビリルビン大量負荷時の胆汁中ビリルビン排泄機構
https://kindai.repo.nii.ac.jp/records/2002200
https://kindai.repo.nii.ac.jp/records/200220083f9af96-73ef-450f-8d12-c572c72b5673
| 名前 / ファイル | ライセンス | アクション |
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AN00063584-19930625-0181.pdf (517.0 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2024-12-20 | |||||||||
| タイトル | ||||||||||
| タイトル | Wistar Kyotoラットにおけるビリルビン大量負荷時の胆汁中ビリルビン排泄機構 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Biliary bilirubin excretion in Wistar Kyoto rat under loading of bilirubin | |||||||||
| 言語 | en | |||||||||
| 著者 |
川崎, 紀彦
× 川崎, 紀彦
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | bilirubin, bile acid, biliary excretion, UDP-glucuronic acid, Wistar Kyoto rat | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 18, 号 2, p. 181-190, 発行日 1993-06-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The mechanism of biliary bilirubin excretion in Wistar Kyoto rats was studied. Bilirubin diglucuronide is a main fraction of biliary bilirubin in Wistar Kyoto rats, and is similar to that of humans but differs from that of control (SD and Wistar) rats. Large amounts of bilirubin were loaded intravenously to Wistar Kyoto rats and Wistar rats with or without intraperitoneal salicylamide administration. Hepatic uridine diphosphate (UDP)-glucuronic acid concentration, bile flow, bile acid excretion, bilirubin fraction and biliary bilirubin excretion were determined. Bile flow and bile acid concentration and output did not different between the bilirubin loaded group and the bilirubin load +salicylamide group. Administration of salicylamide caused hepatic UDP-glucuronic acid concentration to decrease to about one twentieth of the pretreatment level of salicylamide. Since salicylamide is metabolized through glucuronidation, it consumes hepatic UDP-glucuronic acid. Biliary bilirubin diglucuronide fraction was slightly decreased and bilirubin monoglucuronide fraction was slightly increased after bilirubin loading in both strains of rats. These changes were remarkable in rats receiving the co-administration of salicylamide. In Wistar Kyoto rats, total biliary bilirubin excretion decreased with the delayed and decreased excretion of bilirubin diglucuronide fraction. Biliary bilirubin monoglucuronide excretion decreased after bilirubin loading in Wistar Kyoto rats, but the administration of salicylamide did not delay its excretion. There may be a decreased excretion of bilirubin monoglucuronide in Wistar Kyoto rats. From these results, it was concluded that there is a difference in biliary bilirubin excretion between the two strains of rats. In addition, it was concluded that the canalicular excretory pathway of bile acid is different from that of bilirubin. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
